Palladium(II) Acetate Catalyzed Cyclization–Coupling of (o-Ethynylphenyl)phosphonic Acid Monoesters with Allyl Halides

Abstract

A Pd(OAc)₂-catalyzed tandem cyclization–coupling reaction of (o-ethynylphenyl)phosphonic acid monoesters and allyl halides has been developed. This reaction provides an efficient, mild, general and regioselective way to synthesize 4-allylphosphaisocoumarins.

Key words

cyclizations - coupling - tandem reactions - palladium(II) catalysis - phosphorus heterocycles - allylation

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