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Synthesis 2019; 51(19): 3747-3757
DOI: 10.1055/s-0039-1690000
DOI: 10.1055/s-0039-1690000
paper
A Simple Synthesis of Densely Substituted Benzofurans by Domino Reaction of 2-Hydroxybenzyl Alcohols with 2-Substituted Furans
This work was supported by the Russian Science Foundation (Grant No. 17-73-10349).Further Information
Publication History
Received: 17 April 2019
Accepted after revision: 13 June 2019
Publication Date:
03 July 2019 (online)
Abstract
The Brönsted acid-catalyzed cascade synthesis of densely substituted benzofurans from easily available salicyl alcohols and biomass-derived furans has been developed. The disclosed sequence includes the intermediate formation of 2-(2-hydroxybenzyl)furans that quickly rearrange into functionalized benzofurans. The established protocol was applied for the total synthesis of sugikurojinol B.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690000.
- Supporting Information
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