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Synthesis 2020; 52(12): 1779-1794
DOI: 10.1055/s-0039-1690088
DOI: 10.1055/s-0039-1690088
paper
Environmentally Friendly Nafion-Mediated Friedländer Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones
The authors thank Academia Sinica (AS-SUMMIT-108) and Ministry of Science and Technology, Taiwan (MOST 108-3114-Y-001-002 and MOST 108-2113-M-001-019-) for financial support.Further Information
Publication History
Received: 06 February 2020
Accepted after revision: 25 February 2020
Publication Date:
19 March 2020 (online)
Abstract
An efficient and eco-friendly synthetic route for Friedländer quinoline synthesis of polysubstituted quinolines is described. This green chemical method starts from various 2-aminobenzophenones and mono- or dicarbonyl synthons and uses reusable Nafion NR50 material as a solid catalyst in ethanol under microwave irradiation. The protocol has a high generality of functional groups and provides the desired quinolines in good to excellent yields. Some structures were confirmed by single-crystal X-ray diffraction analysis.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690088.
- Supporting Information
- CIF File
-
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