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Synthesis 2020; 52(02): 290-296
DOI: 10.1055/s-0039-1690218
DOI: 10.1055/s-0039-1690218
paper
Metal-Free Synthesis 6-Benzylphenanthridines via Radical Addition/Cyclization of 2-Isocyanobiphenyls
This work is financially supported by the National Natural Science Foundation of China (No. 81102334, 31370372, 31170323), the Program for New Century Excellent Talents in University (State Education Ministry of China; NCET-2008-0224), and the Fundamental Research Funds for the Central Universities (2017KFYXJJ152).Further Information
Publication History
Received: 27 August 2019
Accepted after revision: 02 October 2019
Publication Date:
05 November 2019 (online)
Abstract
A simple and practical approach has been established for the synthesis of 6-benzylphenanthridines from benzylic hydrocarbons and 2-isocyanobiphenyls via C(sp3)–H/C(sp2)–H bond functionalization under metal-free condition. The reaction exhibits good functional group tolerance and delivers the target products in moderate to excellent yields. The preliminary mechanistic investigation revealed that a radical intermediate might be involved in this reaction.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690218.
- Supporting Information
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