Iridium-Catalyzed Asymmetric C–H Borylation Enabled by Chiral Bidentate Boryl Ligands

Yongjia Shi; Qian Gao; Senmiao Xu

doi:10.1055/s-0039-1690225

Synlett, Inhaltsverzeichnis

Synlett 2019; 30(19): 2107-2112
DOI: 10.1055/s-0039-1690225

synpacts

Iridium-Catalyzed Asymmetric C–H Borylation Enabled by Chiral Bidentate Boryl Ligands

Yongjia Shi

^aState Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute, Lanzhou Institute of Chemical Physics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 73000, P. R. of China eMail: senmiaoxu@licp.cas.cn

^bUniversity of Chinese Academy of Sciences, Beijing 100049, P. R. of China

,

Qian Gao

^aState Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute, Lanzhou Institute of Chemical Physics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 73000, P. R. of China eMail: senmiaoxu@licp.cas.cn

,

Senmiao Xu ∗

^aState Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute, Lanzhou Institute of Chemical Physics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Lanzhou 73000, P. R. of China eMail: senmiaoxu@licp.cas.cn

^cKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 311121, P. R. of China

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Abstract

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Abstract

Asymmetric synthesis of optically pure organoboron compounds is a topic that has received a number of attentions owing to their particular importance in synthetic chemistry and drug discovery. We herein highlight recent advances in the iridium-catalyzed C–H borylation of diarylmethylamines and cyclopropanes enabled by chiral bidentate boryl ligands.

1 Introduction

2 Ir-Catalyzed Asymmetric C(sp²)–H Borylation of Diarylmethylamines

3 Ir-Catalyzed Enantioselective C(sp³)–H Borylation of Cyclopropanes

4 Conclusion

Key words

chiral boryl ligand - C–H borylation - asymmetric C–H activation - diarylmethylamine - cyclopropane - iridium - asymmetric catalysis

Volltext

Referenzen

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