α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols

Jin Lan; Guofang Jiang; Jiangnan Yang; Haibo Zhu; Zhanggao Le; Zongbo Xie

doi:10.1055/s-0039-1690883

Synthesis, Table of Contents

Synthesis 2020; 52(14): 2121-2126
DOI: 10.1055/s-0039-1690883

paper

α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols

Jin Lan

,

Guofang Jiang

,

Jiangnan Yang

,

Haibo Zhu

,

Zhanggao Le∗

Department of Applied Chemistry, East China University of Technology, Nanchang 330013, Jiangxi, P. R. of China Email: zhgle@ecut.edu.cn Email: zbxie@ecut.edu.cn

,

Zongbo Xie∗

Department of Applied Chemistry, East China University of Technology, Nanchang 330013, Jiangxi, P. R. of China Email: zhgle@ecut.edu.cn Email: zbxie@ecut.edu.cn

› Author Affiliations

Abstract

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Abstract

This is the first report of a simple and general method for acetalization of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral conditions in good yields using a catalytic amount of chymotrypsin.

Key words

α-chymotrypsin - acetalization - biocatalysis - green chemistry

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References

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