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Synthesis 2020; 52(05): 763-768
DOI: 10.1055/s-0039-1691528
DOI: 10.1055/s-0039-1691528
paper
Direct Oxidative Dearomatization of Indoles with Aromatic Ketones: Rapid Access to 2,2-Disubstituted Indolin-3-ones
This work was financially supported by the National Natural Science Foundation of China (No. 21801093) and the Natural Science Foundation of Shandong Province (Nos. ZR2017BB006, JQ201721).Weitere Informationen
Publikationsverlauf
Received: 16. Oktober 2019
Accepted after revision: 16. November 2019
Publikationsdatum:
28. November 2019 (online)
§ These authors contributed equally to this work
Abstract
A metal-free oxidative dearomatization of indoles with aromatic ketones mediated by TEMPO oxoammonium salt is described. The dearomatization proceeds smoothly and displays a broad substrate scope with respect to both indoles and aromatic ketones in the presence of H2SO4, affording the corresponding 2,2-disubstituted indolin-3-ones in good yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1691528.
- Supporting Information
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