Enantiodivergent Synthesis of Both PAMPO Enantiomers Using l-Menthyl Chloroacetate and Stereomutation at P in Classical Quaternisation Reactions

Abstract

A practical protocol for efficient synthesis of both PAMPO enantiomers as well as related functionalised P-stereogenic phosphine oxides in 1–3 steps from effectively resolved (S _P)-l-menthyl o-anisyl­-(phenyl)phosphinylacetate has been developed. Examples of non-stereo­selective quaternisation of a tertiary phosphine by alkyl halides have been revealed.

Key words

P-stereogenic phosphine oxides - PAMPO - resolution - phosphines - pyramidal inversion - non-stereoselective quaternisation

• References

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See also:
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