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Synlett 2020; 31(04): 309-314
DOI: 10.1055/s-0039-1691573
DOI: 10.1055/s-0039-1691573
synpacts
Mechanical Interlocking of Macrocycles in Different Sequences
This work is supported by the Croucher Foundation and by a grant from the Research Grants Council, University Grants Committee of the Hong Kong Special Administrative Region (SAR), China (Grant No. HKU 27300014).Further Information
Publication History
Received: 09 December 2019
Accepted after revision: 27 December 2019
Publication Date:
20 January 2020 (online)
![](https://www.thieme-connect.de/media/synlett/202004/lookinside/thumbnails/st-2019-p0663-sp_10-1055_s-0039-1691573-1.jpg)
Abstract
Sequence isomerism is fundamental to the storage, transfer and expression of information in (bio)macromolecules and artificial polymers. Realization of sequence-specific properties in mechanically bonded molecules is extremely challenging due to the huge synthetic difficulty in the precise and controllable non-covalent interlocking of constitutionally different macrocycles in specific orders within a rotaxane or catenane. This Synpacts article highlights how sequence isomers of multicomponent rotaxanes and catenanes can be obtained by novel synthetic strategies and careful building block design.
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For reviews on rotaxanes, catenanes and knots, see