Desai P,
Pfeiffer SS,
Boger DL.
* The Scripps Research Institute, La Jolla, USA
Synthesis of the Chlorofusin Cyclic Peptide: Assignment of the Asparagine Stereochemistry.
Org. Lett. 2003;
5: 5047-5050
Key words
chlorofusin - cyclic peptides - coupling reagents - macrocycles
Significance
Cyclic peptides with unique molecular topologies have attracted attention from the fields of biochemistry and medicinal chemistry. In 2003, Boger and co-workers synthesized the cyclic peptide of chlorofusin, consisting of nine amino acid residues.
Comment
The nine amino acids were assembled from four subunits. Subsequent cyclization using coupling reagents proceeded smoothly to give the 27-membered macrocycle in a moderate yield.
