Abstract
Guillain–Barré syndrome (GBS) is an acute inflammatory polyneuropathy characterized
by rapidly progressive, essentially symmetric weakness and areflexia in a previously
otherwise healthy child. It is the most common cause of acute flaccid paralysis in
children, and its reported incidence is 1 to 2/100,000 population. Prior infection
is a well-established predating event in GBS. The commonly recognized variants of
GBS are acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal
neuropathy (AMAN), acute motor sensory axonal neuropathy, and Miller–Fisher syndrome.
AIDP is the most prevalent form. As Guillain–Barrè syndrome represents an important
differential diagnosis in infancy with pronounced and progressive hypotonia, we herein
report a case of AMAN in a 5-month-old male infant without known exposure to immunomodulating
factors or infections.
Keywords
Guillain–Barrè syndrome - progressive hypotonia - acute motor axonal neuropathy children
