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J Knee Surg 2021; 34(08): 886-897
DOI: 10.1055/s-0039-3402043
Original Article

Factors Associated with Knee Arthroplasty in a Knee Osteoarthritis Patient Cohort Treated with Intra-articular Injections of Hylan G-F 20

Kevin Ong
1   Exponent, Inc., Philadelphia, Pennsylvania
,
Edmund Lau
2   Exponent, Inc., Biomedical Engineering, Menlo Park, California
,
Maria Runa
1   Exponent, Inc., Philadelphia, Pennsylvania
,
William Daley
3   Sanofi, Inc., Bridgewater Township, New Jersey
,
Roy Altman
4   Division of Rheumatology and Immunology, Department of Medicine, Los Angeles, California
› Author Affiliations
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Abstract

Hylan G-F 20 viscosupplementation can be used to treat knee osteoarthritis pain. This study evaluated time to knee arthroplasty (KA), KA risk factors, and health care resource utilization in patients aged ≥18 years with claims in the Optum Clinformatics Data Mart database (2006–2016) for knee osteoarthritis treated with at least one course of hylan G-F 20. Kaplan–Meier analysis estimated KA risk from osteoarthritis diagnosis and first hylan G-F 20 treatment. KA risk factors were determined using multivariate Cox regression. Among 62,033 patients treated with hylan G-F 20 and/or hylan G-F 20 single intra-articular injection, 60 to 64% did not undergo KA 8 years following first injection. KA risk factors from time of osteoarthritis diagnosis and first hylan G-F 20 treatment were similar: increased age, fewer comorbidities, fewer hylan G-F 20 treatments, female sex, and no ultrasound/fluoroscopy for injection guidance. Patients who underwent KA versus those who did not had more office visits and claims for opioids, nonsteroidal anti-inflammatory drugs, and physical therapy. Patients less likely to undergo KA were younger (<40 years), had more comorbidities, received more courses of hylan G-F 20, were males, or received ultrasound/fluoroscopic injection guidance. Patients who did not receive KA versus those who did used fewer health care resources.

Keywords

knee arthroplasty - osteoarthritis - viscosupplementation - hyaluronic acid - hylan G-F 20

Supplementary Material



Publication History

Received: 08 April 2019

Accepted: 10 November 2019

Article published online:
24 December 2019

© 2019. Thieme. All rights reserved.

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