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Vet Comp Orthop Traumatol 2020; 33(03): 212-219
DOI: 10.1055/s-0040-1701650
Original Research
Georg Thieme Verlag KG Stuttgart · New York

Partial Infraspinatus Tendon Transection as a Means for the Development of a Translational Ovine Chronic Rotator Cuff Disease Model

Jeremiah Easley
1   Preclinical Surgical Research Laboratory, Colorado State University, Fort Collins, Colorado, United States
,
James Johnson 
2   Orthopaedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, Colorado, United States
,
Daniel Regan
3   Flint Animal Cancer Center and Department of Microbiology, Immunology, & Pathology, Colorado State University, Fort Collins, Colorado, United States
,
Eileen Hackett
1   Preclinical Surgical Research Laboratory, Colorado State University, Fort Collins, Colorado, United States
,
Anthony A. Romeo
4   Rothman Orthopaedic Institute, New York, New York, United States
,
Ted Schlegel
5   Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, United States
,
Cecily Broomfield
2   Orthopaedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, Colorado, United States
,
Christian Puttlitz
2   Orthopaedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, Colorado, United States
,
Kirk McGilvray 
2   Orthopaedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, Colorado, United States
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Publikationsverlauf

23. Mai 2019

27. Dezember 2019

Publikationsdatum:
31. März 2020 (online)

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Abstract

Objective Rotator cuff tendon tears are the most common soft tissue injuries in the shoulder joint. Various animal models have been described for this condition, but all current translational animal models have inherent weaknesses in their ability to generate chronically degenerated rotator cuff tendons. The objective of this study was to evaluate a partial infraspinatus tendon transection model as a means of creating a chronically degenerated rotator cuff tendon in an ovine model and compare the injury characteristics of this model to those observed in human patients with severe chronic rotator cuff tendon injuries.

Study Design The infraspinatus tendons of six sheep were partially detached followed by capping of the detached medial section of the tendon with Gore-Tex. Human tissue samples of the supraspinatus tendon were harvested from patients undergoing primary reverse shoulder arthroplasty and served as positive controls of chronic rotator cuff tendinopathy.

Results Transected sheep tendons were characterized predominantly by an acute reactive and reparative pathological process as compared with the chronic degenerative changes observed in the human tendons. In contrast, the non-transected portion of the ovine tendon showed histological changes, which were more chronic and degenerative in nature when compared with the transected tendon.

Conclusion Overall, histological features of the non-transected portion of ovine tendon were more similar to those observed in the chronic degenerated human tendon.

Keywords

chronic rotator cuff degeneration - histopathology - preclinical model - sheep - supraspinatus tendon

Authors' Contributions

Jeremiah Easley and Kirk McGilvray contributed to the conception of study, study design, acquisition of data and data analysis and interpretation. Eileen Hackett, Tony Romeo, Ted Schlegel and Christian Puttlitz contributed to conception of study and study design. Cecily Broomfield contributed to study design and acquisition of data. James Johnson contributed to acquisition of data and data analysis and interpretation. Daniel Regan contributed to study design, acquisition of data and data analysis and interpretation. All authors drafted, revised and approved the submitted manuscript.