C(sp³)–H Bond Functionalization of Alcohols, Ketones, Nitriles, Ethers and Amides using tert-Butyl Hydroperoxide as a Radical Initiator

Abstract

The C(sp³)–H bond is found widely in organic molecules. Recently, the functionalization of C(sp³)–H bonds has developed into a powerful tool for augmenting highly functionalized frameworks in organic synthesis. Based on the results obtained in our group, the present account mainly summarizes recent progress on the functionalization of C(sp³)–H bonds of aliphatic alcohols, ketones, alkyl nitriles, and ethers with styrene or cinnamic acid using tert-butyl hydroperoxide (TBHP) as a radical initiator.

1 Introduction

2 Oxidative Coupling of Styrenes with C(sp³)–H Bonds

3 Decarboxylative Cross-Couplings of α,β-Unsaturated Carboxylic Acids with C(sp³)–H Bonds

4 Conclusions

Key words

C(sp³)–H bond functionalization - radical reactions - styrenes - tert-butyl hydroperoxide - mechanism

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