Palladium(II)-Catalyzed C(sp)–C(sp²) Coupling: A Direct Approach to Multi-Substituted Pyrrolo[1,2-a]pyrazines

Abstract

A direct synthesis of multi-substituted pyrrolo[1,2-a]pyrazines via palladium(II)-catalyzed C(sp)–C(sp²) cascade coupling and intramolecular cyclization in the presence of ligand was developed. This reaction originates from phenylboronic acids and readily synthesized 2-carbonyl- or 2-formylpyrroloacetonitriles, and affords products in good to excellent yields for a diversity of substrates. Additionally, a possible mechanism for the transformation is proposed.

Key words

C–C coupling - palladium - cascade reactions - substituted pyrrolo[1,2-a]pyrazines

Publikationsverlauf

Eingereicht: 28. September 2020

Angenommen nach Revision: 03. Dezember 2020

Artikel online veröffentlicht:
26. Januar 2021

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