Metal-Free Catalytic Aromatic C–H Borylation

Hua Zhang; Li Wang

doi:10.1055/s-0040-1707241

Synlett, Table of Contents

Synlett 2020; 31(19): 1857-1861
DOI: 10.1055/s-0040-1707241

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Metal-Free Catalytic Aromatic C–H Borylation

Hua Zhang ∗

^aCollege of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, P. R. of China

^bKey Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education and Hubei Key Laboratory of Catalysis and Materials Science, School of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan, 430074, P. R. of China Email: huazhang@scuec.edu.cn

,

Li Wang

^aCollege of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang, 330031, P. R. of China

› Author Affiliations

Abstract

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Abstract

In recent decades, C–H borylation has undergone rapid development and has become one of the most important and efficient methods for the synthesis of organoboron compounds. Although transition-metal catalysis dominates C–H borylation, the metal-free approach has emerged as a promising alternative strategy. This article briefly summarizes the history of metal-free aromatic C–H borylation, including early reports on electrophilic C–H borylation and recent progress in metal-free catalytic intermolecular C–H borylation; it also highlights our recent work on BF₃·Et₂O-catalyzed C2–H borylation of hetarenes. Despite these recent advances, comprehensive mechanistic studies on various metal-free catalytic aromatic C–H borylations and novel processes with a wider substrate scope are eagerly expected in the near future.

Key words

C–H activation - borylation - metal-free reaction - catalysis - organoboron compounds

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References

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