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DOI: 10.1055/s-0040-1707339
Intensification of Free-Radical Racemization for a Non-activated Amine in a Continuous Flow Reactor
Publication History
Received: 04 May 2020
Accepted after revision: 26 May 2020
Publication Date:
07 July 2020 (online)
Published as part of the Special Topic Synthesis in Industry
Abstract
The free-radical racemization of non-activated amines is a powerful tool for process design in the pharmaceutical industry, allowing the recycling of undesired enantiomers after chiral separation. This paper describes the development of the free-radical racemization of a key API intermediate in a continuous flow reactor. Upon development, a significant reduction of the solvent usage and radical initiator was made possible thanks to the conversion into a continuous flow mode. This intensification positively impacted both the environmental footprint and the safety of the reaction as well as maintaining satisfactory productivity.
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