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Synthesis 2021; 53(02): 383-390
DOI: 10.1055/s-0040-1707356
DOI: 10.1055/s-0040-1707356
paper
Palladium-Catalyzed Cross-Coupling Reactions of 4-Tosyloxyquinazolines with Indoles: An Efficient Approach to 4-(1H-Indol-1-yl)quinazolines
Financial support from National Natural Science Foundation of China (no. 21362014 and 21762020), Jiangxi Provincial Department of Science and Technology (no. 20171BAB203006), and Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University (no. KLFS-KF-201408) is gratefully acknowledged.Further Information
Publication History
Received: 14 June 2020
Accepted after revision: 27 July 2020
Publication Date:
25 August 2020 (online)
Abstract
In this paper, exploration of our continuous interests on late-stage derivation of quinozaline core is described. A wide array of 4-(1H-indol-1-yl)quinazolines were obtained in good to excellent yields through palladium-catalyzed cross-coupling of 4-tosyloxyquinazolines with indole derivatives under mild reaction conditions.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707356.
- Supporting Information
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For recent Pd-catalyzed amination of aryl tosylates, see:
For Ni-catalyzed amination of aryl tosylates, see: