Download PDF
Journal of Pediatric Epilepsy 2020; 09(02): 051-052
DOI: 10.1055/s-0040-1710585
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Severe Bilateral Cervical Lymphadenomegaly Associated with Ethosuximide

Maria Augusta Montenegro 
1   Department of Neurology, University of Campinas, Campinas, Sao Paulo, Brazil
,
Izilda A. Cardinalli
2   Department of Oncology, Boldrini Children's Center, Campinas, Sao Paulo, Brazil
,
Camila Maia Martin Daiggi
2   Department of Oncology, Boldrini Children's Center, Campinas, Sao Paulo, Brazil
› Author Affiliations Funding None.
Further Information

Publication History

26 February 2020

15 April 2020

Publication Date:
12 May 2020 (online)

Also available at
    Permissions and Reprints

Abstract

Lymphadenomegaly associated with antiepileptic drugs is well documented; however, severe lymphadenopathy mimicking a neoplasm is a rare adverse event associated with antiepileptic drugs. It is usually characterized by a large cervical mass associated with fever, weight loss, skin rash, and abnormal complete blood count (atypical lymphocytes, eosinophilia, and abnormal neutrophil count). In this case report, we described a child with severe bilateral cervical lymphadenomegaly associated with ethosuximide, in which excisional biopsy of the enlarged nodes was needed to establish the final diagnosis. Prognosis was excellent after drug discontinuation.

Keywords

absence - childhood - lymphadenomegaly - ethosuximide
 

  • References

  • 1 Glauser TA, Cnaan A, Shinnar S. , et al; Childhood Absence Epilepsy Study Group. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. N Engl J Med 2010; 362 (09) 790-799
    CrossrefPubMedSearch in Google Scholar
  • 2 Charlesworth EN. Phenytoin-induced pseudolymphoma syndrome: an immunologic study. Arch Dermatol 1977; 113 (04) 477-480
    CrossrefPubMedSearch in Google Scholar
  • 3 Yates P, Stockdill G, McIntyre M. Hypersensitivity to carbamazepine presenting as pseudolymphoma. J Clin Pathol 1986; 39 (11) 1224-1228
    CrossrefPubMedSearch in Google Scholar
  • 4 Mulroy E, Walker E. Lamotrigine-related pseudolymphoma presenting as cervical lymphadenopathy. Epilepsy Behav Case Rep 2017; 7: 40-41
    PubMedSearch in Google Scholar
  • 5 Werbel T, Castrovinci P, Contestable J. Ethosuximide-induced drug reaction with eosinophilia and systemic symptoms with mediastinal lymphadenopathy. Pediatr Dermatol 2019; 36 (04) e99-e101
    PubMedSearch in Google Scholar
  • 6 Masruha MR, Marques CM, Vilanova LC, de Seixas Alves MT, Peres MF, Rodrigues MG. Drug induced pseudolymphoma secondary to ethosuximide. J Neurol Neurosurg Psychiatry 2005; 76 (11) 1610
    PubMedSearch in Google Scholar
  • 7 Shiohara T, Mizukawa Y. Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): an update in 2019. Allergol Int 2019; 68 (03) 301-308
    CrossrefPubMedSearch in Google Scholar