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J Neurol Surg A Cent Eur Neurosurg 2021; 82(04): 357-363
DOI: 10.1055/s-0040-1721757
Original Article

fMRI Resting-State Connectivity between Language and Nonlanguage Areas as Defined by Intraoperative Electrocortical Stimulation in Low-Grade Glioma Patients

Jasper van Lieshout
1   Department of Neurosurgery, Universitatsklinikum Dusseldorf, Dusseldorf, Nordrhein-Westfalen, Germany
,
Wouter Debaene
2   Department of Cognitive Neuropsychology, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, Noord-Brabant, The Netherlands
,
Marion Rapp
1   Department of Neurosurgery, Universitatsklinikum Dusseldorf, Dusseldorf, Nordrhein-Westfalen, Germany
,
Herke Jan Noordmans
3   Medical Technology, UMC Utrecht, Utrecht, The Netherlands
,
Geert-Jan Rutten 
4   Department of Neurosurgery, Elisabeth-TweeSteden Ziekenhuis, Tilburg, The Netherlands
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Abstract

Background and Objectives It remains to be determined whether noninvasive functional imaging techniques can rival the clinical potential of direct electrocortical stimulation (DES). In this study, we compared the results of resting-state functional magnetic resonance imaging (rs-fMRI) to those of DES for language mapping. Our goals were twofold: (1) to replicate a previous study that demonstrated that resting-state connectivity (RSC) was significantly larger between positive DES language sites than between negative DES language sites and (2) to compare the spatial resolution of rs-fMRI to that of DES.

Methods We conducted a retrospective study of nine low-grade glioma patients. Language sites were identified by intraoperative DES. We compared RSC values between and within groups of DES-positive and DES-negative regions of interest (ROIs). Both close-negative sites (i.e., DES-negative sites <1 cm apart from and on the same gyrus as DES-positive sites) and far-negative sites (i.e., purely randomly chosen sites not in the vicinity of the tumor or of the DES-positive sites but on the same lobe) were included. Receiver operating characteristics were used to quantify comparisons.

Results Functional connectivity between all positive language sites was on average significantly higher than between all close-negative sites and between all far-negative sites. The functional connectivity between the positive language ROIs and their respective close-negative control sites was not smaller than between all positive language sites.

Conclusion rs-fMRI likely reflects similar neural information as detected with DES, but in its current form does not reach the spatial resolution of DES.

Keywords

resting-state fMRI - direct electrocortical stimulation - language - glioma


Publication History

Received: 18 April 2020

Accepted: 22 June 2020

Article published online:
22 February 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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