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Intensivmedizin up2date 2015; 11(02): 161-176
DOI: 10.1055/s-0041-101343
DOI: 10.1055/s-0041-101343
Neuro-Intensivmedizin
Dekompressive Hemikraniektomie beim malignen Mediainfarkt
Further Information
Publication History
Publication Date:
28 April 2015 (online)
![](https://www.thieme-connect.de/media/intensiv-u2d/201502/lookinside/thumbnails/226_10-1055-s-0041-101343-1.jpg)
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Die DHC wird zunehmend häufiger zur Behandlung des MMI eingesetzt, auch wenn die absolute Zahl der Eingriffe aufgrund der Seltenheit der Erkrankung gering bleibt.
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Neueste Studien aus der Neuroradiologie legen eine zuverlässige frühe Vorhersage eines MMI anhand der Infarktausdehnung, der Schwere des Perfusionsdefizits und des intrakraniellen Reservevolumens nahe.
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Die bekannte Effektivität der DHC bei der Behandlung jüngerer MMI-Patienten wurde auch bei älteren Patienten nachgewiesen, der Behandlungseffekt ist jedoch geringer.
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Da ältere Patienten ein weniger gutes Behandlungsergebnis erreichen, wird die Debatte um das akzeptable Maß an Behinderung bei Überlebenden eines MMI erneut aufleben.
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Literatur
- 1 Hacke W, Schwab S, Horn M et al. „Malignant“ middle cerebral artery territory infarction: clinical course and prognostic WAsigns. Arch Neurol 1996; 53: 309-315
- 2 Ng LK, Nimmannitya J. Massive cerebral infarction with severe brain swelling: a clinicopathological study. Stroke 1970; 1: 158-163
- 3 Jaramillo A, Góngora-Rivera F, Labreuche J et al. Predictors for malignant middle cerebral artery infarctions: a postmortem analysis. Neurology 2006; 66: 815-820
- 4 Uhl E, Kreth FW, Elias B et al. Outcome and prognostic factors of hemicraniectomy for space occupying cerebral infarction. J Neurol Neurosurg Psychiatry 2004; 75: 270-274
- 5 Menon BK, Bal S, Modi J et al. Anterior temporal artery sign in CT angiography predicts reduced fatal brain edema and mortality in acute M1 middle cerebral artery occlusions. J Neuroimaging 2012; 22: 145-148
- 6 Simard JM, Kent TA, Chen M et al. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol 2007; 6: 258-268
- 7 Poca MA, Benejam B, Sahuquillo J et al. Monitoring intracranial pressure in patients with malignant middle cerebral artery infarction: is it useful?. J Neurosurg 2010; 112: 648-657
- 8 Bardutzky J, Schwab S. Antiedema therapy in ischemic stroke. Stroke 2007; 38: 3084-3094
- 9 Jüttler E, Schwab S, Schmiedek P et al. Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial. Stroke 2007; 38: 2518-2525
- 10 Vahedi K, Vicaut E, Mateo J et al. Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial). Stroke 2007; 38: 2506-2517
- 11 Hofmeijer J, Kapelle LJ, Algra A et al. Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial (HAMLET]): a multicentre, open, randomised trial. Lancet Neurol 2009; 8: 326-333
- 12 Van der Worp HB, Macleod MR, Kollmar R. European Stroke Research Network for Hypothermia (EuroHYP). Therapeutic hypothermia for acute ischemic stroke: ready to start large randomized trials?. J Cereb Blood Flow Metab 2010; 30: 1079-1093
- 13 Els T, Oehm E, Voigt S et al. Safety and therapeutical benefit of hemicraniectomy combined with mild hypothermia in comparison with hemicraniectomy alone in patients with malignant ischemic stroke. Cerebrovasc Dis 2006; 21: 79-85
- 14 Neugebauer H, Kollmar R, Niesen WD et al. DEcompressive surgery Plus hypoTHermia for Space-Occupying Stroke (DEPTH-SOS): a protocol of a multicenter randomized controlled clinical trial and a literature review. Int J Stroke 2013; 8: 383-387
- 15 Unterberg A, Juettler E. The role of surgery in ischemic stroke: decompressive surgery. Curr Opin Crit Care 2007; 13: 175-179
- 16 Jüttler E, Köhrmann M, Aschoff A et al. Hemicraniectomy for space-occupying supratentorial ischemich stroke. Future Neurol 2008; 3: 251-264
- 17 Wagner S, Schnippering H, Aschoff A et al. Suboptimum hemicraniectomy as a cause of additional cerebral lesions in patients with malignant infarction of the middle cerebral artery. J Neurosurg 2001; 94: 693-696
- 18 Staykov D, Gupta R. Hemicraniectomy in malignant middle cerebral artery infarction. Stroke 2011; 42: 513-516
- 19 Fischer U, Taussky P, Gralla J et al. Decompressive craniectomy after intra-arterial thrombolysis: safety and outcome. J Neurol Neurosurg Psychiatry 2011; 82: 885-887
- 20 Takeuchi S, Wada K, Nawashiro H et al. Decompressive craniectomy after intravenous tissue plasminogen activator administration for stroke. Clin Neurol Neurosurg 2012; 114: 1312-1315
- 21 Vahedi K, Hofmeijer J, Juettler E et al. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol 2007; 6: 215-222
- 22 Bar M, Mikulik R, Skoloudik D et al. Decompressive surgery for malignant supratentorial infarction remains underutilized after guideline publication. J Neurol 2011; 258: 1689-1694
- 23 Adeoye O, Hornung R, Khatri P et al. The rate of hemicraniectomy for acute ischemic stroke is increasing in the United States. J Stroke Cerebrovasc Dis 2011; 20: 251-254
- 24 Bhattacharya P, Kansara A, Chaturvedi S et al. What drives the increasing utilisation of hemicraniectomy in acute ischaemic stroke?. Neurol Neurosurg Psychiatry 2013; 84: 727-731
- 25 Rahme R, Curry R, Kleindorfer D et al. How often are patients with ischemic stroke eligible for decompressive hemicraniectomy?. Stroke 2012; 43: 550-552
- 26 Balzer B, Stober T, Huber G et al. Space-occupying cerebral infarct. Nervenarzt 1987; 58: 689-691
- 27 Gupta R, Connolly ES, Mayer S et al. Hemicraniectomy for massive middle cerebral artery territory infarction: a systematic review. Stroke 2004; 35: 539-543
- 28 Arac A, Blanchard V, Lee M et al. Assessment of outcome following decompressive craniectomy for malignant middle cerebral artery infarction in patients older than 60 years of age. Neurosurg Focus 2009; 26: E3
- 29 Jüttler E, Unterberg A, Woitzik J et al. Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke. N Engl J Med 2014; 370: 1091-1100
- 30 Hofmeijer J, Algra A, Kappelle LJ et al. Predictors of life-threatening brain edema in middle cerebral artery infarction. Cerebrovasc Dis 2008; 25: 176-184
- 31 Oppenheim C, Samson Y, Manaï R et al. Prediction of malignant middle cerebral artery infarction by diffusion-weighted imaging. Stroke 2000; 31: 2175-2181
- 32 Thomalla GJ, Kucinski T, Schoder V et al. Prediction of malignant middle cerebral artery infarction by early perfusion- and diffusion-weighted magnetic resonance imaging. Stroke 2003; 34: 1892-1899
- 33 Thomalla G, Hartmann F, Juettler E et al. Prediction of malignant middle cerebral artery infarction by magnetic resonance imaging within 6 hours of symptom onset: A prospective multicenter observational study. Ann Neurol 2010; 68: 435-445
- 34 Dohmen C, Bosche B, Graf R et al. Prediction of malignant course in MCA infarction by PET and microdialysis. Stroke 2003; 34: 2152-2158
- 35 Dohmen C, Galldiks N, Bosche B et al. The severity of ischemia determines and predicts malignant brain edema in patients with large middle cerebral artery infarction. Cerebrovasc Dis 2012; 33: 1-7
- 36 Serena J, Blanco M, Castellanos M et al. The prediction of malignant cerebral infarction by molecular brain barrier disruption markers. Stroke 2005; 36: 1921-1926
- 37 Minnerup J, Wersching H, Ringelstein EB et al. Prediction of malignant middle cerebral artery infarction using computed tomography-based intracranial volume reserve measurements. Stroke 2011; 42: 3403-3409
- 38 Burghaus L, Liu WC, Dohmen C et al. Prognostic value of electroencephalography and evoked potentials in the early course of malignant middle cerebral artery infarction. Neurol Sci 2013; 34: 671-678
- 39 Sykora M, Steiner T, Rocco A et al. Barore- flex sensitivity to predict malignant middle cerebral artery infarction. Stroke 2012; 43: 714-719
- 40 Van Swieten JC, Koudstaal PJ, Visser MC et al. Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1988; 19: 604-607
- 41 Greco T. Le thrombosi posttraumatiche della carotid. Arch Ital Chir 1935; 39: 757-784
- 42 Zhao J, Su YY, Zhang Y et al. Decompressive hemicraniectomy in malignant middle cerebral artery infarct: a randomized controlled trial enrolling patients up to 80 years old. Neurocrit Care 2012; 17: 161-171
- 43 Frank JI, Schumm LP, Wroblewski K et al. Hemicraniectomy and durotomy upon deterioration from infarction-related swelling trial: randomized pilot clinical trial. Stroke 2014; 45: 781-787
- 44 Mitchell P, Gregson BA, Crossman J et al. Reassessment of the HAMLET study. Lancet Neurol 2009; 8: 602-603 ; author reply 603–604
- 45 Lucas C, Thines L, Dumont F et al. Decompressive surgery for malignant middle cerebral artery infarcts: the results of randomized trials can be reproduced in daily practice. Eur Neurol 2012; 68: 145-149
- 46 Puetz V, Campos CR, Eliasziw M et al. Assessing the benefits of hemicraniectomy: what is a favourable outcome?. Lancet Neurol 2007; 6: 580-581
- 47 World Health Organization. International Classification of Functioning, Disability and Health (ICF). Geneva: WHO; 2003
- 48 Albrecht GL, Devlieger PJ. The disability paradox: high quality of life against all odds. Soc Sci Med 1999; 48: 977-988
- 49 Creutzfeldt CJ, Holloway RG. Treatment decisions after severe stroke: uncertainty and biases. Stroke 2012; 43: 3405-3408
- 50 Rahme R, Zuccarello M, Kleindorfer D et al. Decompressive hemicraniectomy for malignant middle cerebral artery territory infarction: is life worth living?. J Neurosurg 2012; 117: 749-754
- 51 Kelly AG, Holloway RG. Health state preferences and decision-making after malignant middle cerebral artery infarctions. Neurology 2010; 75: 682-687
- 52 Walz B, Zimmermann C, Böttger S et al. Prognosis of patients after hemicraniectomy in malignant middle cerebral artery infarction. J Neurol 2002; 249: 1183-1190
- 53 von Sarnowski B, Kleist-Welch Guerra W, Kohlmann T et al. Long-term health-related quality of life after decompressive hemicraniectomy in stroke patients with life-threatening space-occupying brain edema. Clin Neurol Neurosurg 2012; 114: 627-633
- 54 Foerch C, Lang JM, Krause J et al. Functional impairment, disability, and quality of life outcome after decompressive hemicraniectomy in malignant middle cerebral artery infarction. J Neurosurg 2004; 101: 248-254
- 55 Neugebauer H, Heuschmann PU, Jüttler E. DEcompressive Surgery for the Treatment of malignant INfarction of the middle cerebral arterY – Registry (DESTINY-R): design and protocols. BMC Neurol 2012; 12: 115
- 56 Kastrau F, Wolter M, Huber W et al. Recovery from aphasia after hemicraniectomy for infarction of the speech-dominant hemisphere. Stroke 2005; 36: 825-829
- 57 Parikh RM, Robinson RG, Lipsey JR et al. The impact of poststroke depression on recovery in activities of daily living over a 2-year follow-up. Arch Neurol 1990; 47: 785-789
- 58 Neugebauer H, Creutzfeldt CJ, Hemphill 3rd JC et al. DESTINY-S: attitudes of physicians toward disability and treatment in malignant MCA infarction. Neurocrit Care 2014; 21: 27-34
- 59 Schwab S, Steiner T, Aschoff A et al. Early hemicraniectomy in patients with complete middle cerebral artery infarction. Stroke 1998; 29: 1888-1893
- 60 Cho DY, Chen TC, Lee HC. Ultra-early decompressive craniectomy for malignant middle cerebral artery infarction. Surg Neurol 2003; 60: 227-232