Medikamentöse Behandlung der Adipositas

Kernaussagen

• In begründeten Fällen ist eine medikamentöse Unterstützung der Gewichtsreduktion gerechtfertigt. Die Leitlinien der Deutschen Adipositas-Gesellschaft geben hierfür den Rahmen vor.

• Durchschnittlich kann zusätzlich zu einem Basisprogramm mit Lebensstilmodifikationen eine Gewichtsreduktion von etwa 3 – 7 kg durch adjuvante medikamentöse Therapie erzielt werden.

• Aktuell ist in Deutschland nur ein Medikament mit Wirksamkeitsnachweis verfügbar: der Lipasehemmer Orlistat.

• Andere verschreibungspflichtige oder apothekenpflichtige Medikamente ohne Wirksamkeitsnachweis sollten nicht verordnet werden.

• Die Markteinführung der in Europa in diesem Jahr für die Gewichtsreduktion zugelassenen Liraglutid und Naltrexon/Bupropion lässt auf sich warten.

• Besonders zu beachten sind stets kardiovaskuläre und psychische unerwünschte Wirkungen sowie Arzneimittelinteraktionen.

• Vom Off-Label-Einsatz von Medikamenten mit gewichtsreduzierender Wirkung als Nebeneffekt ist dringend abzuraten.

Publication History

Publication Date:
14 January 2016 (online)

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