Acetylsalicylsäure – von der kardiovaskulären zur Karzinomprävention

Zusammenfassung

Kardiovaskuläre Erkrankungen und Tumorerkrankungen stellen nach wie vor weltweit die führenden Ursachen für Morbidität und Mortalität dar [1]. Durch die niedrig dosierte Gabe von ASS bei Patienten mit okklusiven kardiovaskulären Erkrankungen wie Koronare Herzerkrankung (KHK), periphere arterielle Verschlusskrankheit (pAVK) oder Schlaganfall, können ca. 20 % der thrombotischen vaskulären Komplikationen verhindert werden [2]. Insbesondere in der kardiovaskulären Sekundärprävention zeigt sich ein günstiges Nutzen-Risikoprofil einer ASS-Dauermedikation. Inwiefern ASS auch in der Primärprävention kardiovaskulärer Erkrankungen indiziert ist, wird derzeit noch kontrovers diskutiert. Ziel dieser Arbeit ist es, eine aktuelle Übersicht über die Evidenz einer niedrig dosierten ASS-Therapie in der Primär- und Sekundärprävention kardiovaskulärer Erkrankungen zu geben und darüber hinaus den möglichen zusätzlichen Nutzen einer ASS-Therapie in der Prävention von Tumoren zu diskutieren

Abstract

Cardiovascular disease and cancer are the leading causes of morbidity and mortality worldwide. Low-dose ASA has been shown to effectively prevent about one fifth of atherothrombotic vascular complications in patients with previous myocardial infarction, peripheral arterial occlusive disease (PAOD), or stroke [2]. In secondary prevention, the benefits of antiplatelet therapy substantially exceed its risk [2]. By contrast, recommendations for the use of ASA in primary prevention are still a matter of controversy. The aim of this article is to review the current evidence for the efficacy of low-dose ASA in primary and secondary prevention of cardiovascular diseases as well as to discuss its potential additional chemopreventive action.

Schlüsselwörter

kardiovaskuläre Prävention - Chemoprävention - ASS - Aspirin

Keywords

cardiovascular prevention - chemoprevention - ASS - aspirin

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