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Planta Med 2016; 82(09/10): 888-896
DOI: 10.1055/s-0042-103687
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Secondary Metabolites from the Culture of the Marine Sponge-Associated Fungi Talaromyces tratensis and Sporidesmium circinophorum

Suradet Buttachon
1   ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
2   Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Porto, Portugal
,
War War May Zin
1   ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
2   Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Porto, Portugal
,
Tida Dethoup
3   Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Chatuchak, Bangkok, Thailand
,
Luís Gales
1   ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
4   Instituto de Biologia Celular e Molecular (IBMC) & Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal
,
José A. Pereira
1   ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
,
Artur M. S. Silva
5   Departamento de Química & QOPNA, Universidade de Aveiro, Aveiro, Portugal
,
Anake Kijjoa
1   ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal
2   Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Porto, Portugal
› Author Affiliations
Further Information

Publication History

received 27 September 2015
revised 08 February 2016

accepted 12 February 2016

Publication Date:
07 April 2016 (online)

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Abstract

Wortmin (1), meso-1,4-bis(4-methoxybenzyl)-2,3-butanediol (2), and a new isocoumarin derivative tratenopyrone (3) were isolated from the marine sponge-associated fungus Talaromyces tratensis KUFA 0091. A new diphenyl ether derivative, circinophoric acid (4), was isolated, together with the previously reported anthraquinones catenarin and physcion, the benzophenone monomethylsoluchrin, and β-ergosterol-5,8-endoperoxide, from the marine sponge-associated fungus Sporidesmium circinophorum KUFA 0043. The structures of the new compounds were established based on an extensive analysis of 1D and 2D NMR spectra, and, in the case of compounds 2–4, also by X-ray analysis. All of the isolated compounds were tested for their antibacterial activity against Gram-positive and Gram-negative bacteria, and multidrug-resistant isolates from the environment, as well as for their anti-quorum sensing based on the pigment production of Chromobacterium violaceum ATCC 31523. None of the compounds exhibited either antibacterial (MIC > 256 µg/mL) or anti-quorum sensing activities. The compounds were also inactive in the antifungal (MIC > 512 µg/mL) and cancer cell line (GI50 > 150 µM) assays.

Key words

Talaromyces tratensis - Trichocomaceae - Sporidesmium circinophorum - Dothideomycetes - marine sponge-associated fungi - azaphilone - isocoumarin - diphenyl ether - wortmin

Supporting Information

 

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