Impact of the Ile105Val Polymorphism of the Glutathione S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic Risk in Young Adult Population

E. O. Chielle; A. Trott; B. da Silva Rosa; J. N. Casarin; P. C. Fortuna; I. B. M. da Cruz; M. B. Moretto; R. N. Moresco

doi:10.1055/s-0042-105279

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2017; 125(05): 335-341
DOI: 10.1055/s-0042-105279

Article

Impact of the Ile¹⁰⁵Val Polymorphism of the Glutathione S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic Risk in Young Adult Population

E. O. Chielle

¹Center for Health Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil

³Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil

,

A. Trott

³Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil

,

B. da Silva Rosa

³Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil

,

J. N. Casarin

³Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil

,

P. C. Fortuna

³Laboratory of Molecular Biology, University of Western Santa Catarina, UNOESC, São Miguel do Oeste – SC – Brazil

,

I. B. M. da Cruz

²Center of Natural and Exact Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil

,

M. B. Moretto

¹Center for Health Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil

,

R. N. Moresco

¹Center for Health Sciences, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil

› Author Affiliations

Abstract

The aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged≥18 and ≤30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile¹⁰⁵Val gene polymorphism of the study participants. Also, biochemical analysis and hormone assays were carried out. A positive association between GSTP1 polymorphism and obesity was observed on subjects carrying at least one G allele (AG and GG). GG genotype was found only in the obese group. The G allele carriers presented 2.4 times higher chance of obesity when compared to those with the AA genotype. These results were independent of sex and age. We suggest that despite a study in population regional (south of Brazil), the GSTP1 gene polymorphism may play a significant role in the increase of susceptibility of obesity and contribute to identify the cardiovascular risk in young adults.

Key words

obesity - glutathione - polymorphism - biomarkers - cardiometabolic

Full Text

References

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