Planta Medica, Inhaltsverzeichnis Planta Med 2017; 83(03/04): 217-223DOI: 10.1055/s-0042-111440 Biological and Pharmacological Activity Original Papers Georg Thieme Verlag KG Stuttgart · New York Guaiane-Type Sesquiterpenoids from Fissistigma oldhamii Inhibit the Proliferation of Synoviocytes Xue-Ming Zhou 1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China , Cai-Juan Zheng 1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China , Yu-Qin Zhang 2 Fujian University of Traditional Chinese Medicine College Of Pharmacy, Fuzhou, Fujian, P. R. China , Xiao-Peng Zhang 1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China , Xiao-Ping Song 1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China , Wei Xu 2 Fujian University of Traditional Chinese Medicine College Of Pharmacy, Fuzhou, Fujian, P. R. China , Guang-Ying Chen 1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China › Institutsangaben Artikel empfehlen Abstract Artikel einzeln kaufen Abstract Three guaiane-type sesquiterpenoids, dysodensiols G–I (1–3), together with five known sesquiterpenoids (4–8) were isolated from the stems of Fissistigma oldhamii (Hemsl.) Merr. Compound 1 represents the first example of an ene(6 → 5)-abeo-14-norguaiane sesquiterpenoid derived from natural products. Their structures were elucidated by a combination of 1D and 2D NMR and MS spectra. The absolute configuration of 2 was determined by an X-ray crystallographic analysis. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. 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