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Planta Med 2017; 83(03/04): 334-340
DOI: 10.1055/s-0042-116438
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Bioactive Lupane and Hopane Triterpenes from Lepisanthes senegalensis

Pornwimon Lomchid
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Pitak Nasomjai
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Somdej Kanokmedhakul
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Jaursup Boonmak
2   Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Sujittra Youngme
2   Materials Chemistry Research Center, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
,
Kwanjai Kanokmedhakul
1   Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
› Author Affiliations
Further Information

Publication History

received 26 April 2016
revised 16 August 2016

accepted 29 August 2016

Publication Date:
12 September 2016 (online)

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Abstract

Two lupane and hopane caffeates (1 and 4) and two hopane coumarates (2 and 3) along with eight known compounds (5–12) were isolated from stems and roots of Lepisanthes senegalensis. Their structures were established on the basis of spectroscopic techniques. The structure of compound 2 was confirmed by single-crystal X-ray diffraction analysis. Triterpenes 1 and 4–6 showed cytotoxicity against the NCI-H187 cell line with IC50 values of 31.5, 28.5, 16.2, and 4.0 µM, respectively. However, these compounds also showed cytotoxicity against Vero cells, with IC50 values of 75.5, 16.6, 8.9, and 5.0 µM, respectively. In addition, compound 6 exhibited a moderate antimalarial activity with an IC50 value of 4.5 µM.

Key words

Lepisanthase senegalensis - Sapindaceae-triterpene caffeate - hopane coumarate-antimalarial - cytotoxicity

Supporting Information

 

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