Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole

Abstract

The unique reactivity and beneficial features of the 5-aminotetrazole synthon (1H-tetrazol-5-amine) have made it a versatile and effective building block in the synthesis of heterocyclic compounds. In addition, several drugs containing this scaffold with a wide array of biological properties have been already introduced. Heterocyclic structures are the backbone of many biologically active and industrially important compounds. 5-Aminotetrazole is one of the favored synthons used in the preparation of heterocycle-bearing compounds, especially in multicomponent synthesis. This review highlights a comprehensive overview of the emerging applications of 5-aminotetrazole as a key component in the synthesis of heterocyclic frameworks through multicomponent reactions, reported between 2017 and July 2023.

1 Introduction

2 5-Aminotetrazole

3 Tetrazolopyrimidine Compounds

4 Spiro Compounds

5 Miscellaneous

6 Conclusion

Key words

1H-tetrazol-5-amine - 5-aminotetrazole - heterocycles - multicomponent reactions - synthesis

Publication History

Received: 24 August 2023

Accepted after revision: 24 October 2023

Article published online:
08 January 2024

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