Synthesis 2024; 56(11): 1765-1774
DOI: 10.1055/s-0042-1751545
short review

Recent Advances in Quinoline-Based Macrocycles: Synthesis, Properties, and Applications in Catalytic Reactions

Wei Xu
a   Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan
,
Naoya Kumagai
a   Graduate School of Pharmaceutical Sciences, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan
b   Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan
› Author Affiliations
This work was financially supported by JSPS KAKENHI Grant Number JP19K22192 (Grant-in-Aid for Exploratory Research, to N.K.), JP20H02746 (Grant-in-Aid for Scientific Research (B), to N.K.), and 22K14670 (Grant-in-Aid for Early Career Scientists, to W.X.). N.K. thanks the Izumi Science and Technology Foundation, Toyo Gosei Memorial Foundation, Sumitomo Foundation, and Mitsubishi Foundation for financial support.


Abstract

Macrocyclic compounds exhibit unique properties due to their large ring-shaped structures, which have captivated chemists in recent decades. These molecules exert specific functions in various applicable fields, such as chemistry, materials science, and biology. Crown ethers, calixarenes, and porphyrinoids, which contain several ether/phenol/pyrrole subunits, represent these molecular categories with unparalleled functional diversity. In contrast, quinoline-based macrocycles comprising the quinoline unit as a key element to construct specific ring shapes have received limited attention. In this minireview, we summarize the recent advances in oligoquinoline macrocycles TriQuinoline (TQ), oxa-TriQuinoline (o-TQ), TEtraQuinoline (TEQ), and other bridged quinoline-based macrocycles. Emphasis is placed on the synthesis, structure, and application of these molecules in organometallic and supramolecular chemistry, which may guide new molecular designs in the quinoline-based macrocycle family.

1 Introduction

2 Quinoline-Based Macrocycles

2.1 TriQuinoline (TQ)

2.2 Oxa-TriQuinoline (o-TQ)

2.3 TEtraQuinoline (TEQ)

2.4 Larger Quinoline-Based Macrocycles with Bridges

3 Conclusion



Publication History

Received: 27 October 2023

Accepted after revision: 11 December 2023

Article published online:
23 January 2024

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