Synthesis 2024; 56(14): 2223-2233
DOI: 10.1055/s-0042-1751552
short review

Stereodivergent Carbon–Carbon Bond-Forming Reactions

Alan R. Healy
A.R.H. thanks New York University Abu Dhabi (NYUAD) for funding.


Abstract

Stereodivergent catalysis has emerged as a compelling strategy for achieving stereochemical diversity in small-molecule library design and natural product synthesis. In this short review, key examples of pioneering catalytic carbon–carbon bond-forming transformations that provide access to all stereoisomers of a given product are presented. Current trends and future directions in the field are discussed, highlighting ongoing initiatives to enhance the efficiency and broaden the scope of stereodivergent methodologies.

1 Introduction

2 Mono-catalysis

2.1 Change of Reaction Conditions

2.2 Change of Catalyst

3 Multi-catalysis

3.1 Bifunctional Catalysis

3.2 Sequential/Cascade Catalysis

3.3 Synergistic/Cooperative Catalysis

4 Conclusions and Outlook



Publication History

Received: 15 December 2023

Accepted after revision: 03 January 2024

Article published online:
29 January 2024

© 2024. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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