Stereodivergent Carbon–Carbon Bond-Forming Reactions

Abstract

Stereodivergent catalysis has emerged as a compelling strategy for achieving stereochemical diversity in small-molecule library design and natural product synthesis. In this short review, key examples of pioneering catalytic carbon–carbon bond-forming transformations that provide access to all stereoisomers of a given product are presented. Current trends and future directions in the field are discussed, highlighting ongoing initiatives to enhance the efficiency and broaden the scope of stereodivergent methodologies.

1 Introduction

2 Mono-catalysis

2.1 Change of Reaction Conditions

2.2 Change of Catalyst

3 Multi-catalysis

3.1 Bifunctional Catalysis

3.2 Sequential/Cascade Catalysis

3.3 Synergistic/Cooperative Catalysis

4 Conclusions and Outlook

Key words

stereodivergent synthesis - dual catalysis - sequential catalysis - privileged catalysts - aldol reaction - carbon–carbon bond

Publication History

Received: 15 December 2023

Accepted after revision: 03 January 2024

Article published online:
29 January 2024

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