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DOI: 10.1055/s-0042-1755280
Conus medullaris syndrome in Vogt-Koyanagi-Harada disease: an unusual presentation
Síndrome de cone medular na doença de Vogt-Koyanagi-Harada: uma apresentação não usualA 25-year-old woman presented over one week with subacute flaccid paraparesis, saddle anesthesia and sphincter dysfunction, compatible with conus medullaris syndrome. Lumbar magnetic resonance imaging (MRI) ([Figure 1]) showed spinal cord edema and intense leptomeningeal enhancement. Six months after, she presented with aseptic meningitis and bilateral vision loss. Optical coherence tomography (OCT) showed bilateral exudative retinal detachments ([Figure 2]). Incomplete Vogt-Koyanagi-Harada disease (VKHD) was diagnosed based on the combination of bilateral granulomatous panuveitis and aseptic meningitis.[1] Spinal cord involvement is a frequent manifestation of neurological inflammatory diseases, and VKHD should be considered when typical eye, ear, and skin symptoms are present.[2] [3]
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Conflict of Interest
The authors have no conflict of interests to declare.
Authors' Contributions
FFA: conceptualization, visualization, writing – original draft, and writing – review & editing; MPMM: conceptualization, visualization, writing – original draft, and writing – review & editing; WF: conceptualization, visualization, writing – original draft; FMRF: visualization, writing – original draft; JLP: conceptualization and writing – review & editing; OGPB: conceptualization, visualization, writing – original draft, and writing – review & editing.
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References
- 1 Read RW, Holland GN, Rao NA. et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 2001; 131 (05) 647-652 DOI: 10.1016/S0002-9394(01)00925-4.
- 2 Triplett JD, Buzzard KA, Lubomski M. et al. Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes). J Neurol Neurosurg Psychiatry 2019; 90 (08) 882-894 DOI: 10.1136/jnnp-2018-319002.
- 3 Gu S, Liu Y, Song Z, Zi X, Deng H. Acute myelitis in a patient with vogt-koyanagi-harada disease: case report and review of the literature. J Clin Neurol 2013; 9 (01) 61-64 DOI: 10.3988/jcn.2013.9.1.61.
Address for correspondence
Publication History
Received: 26 January 2022
Accepted: 11 February 2022
Article published online:
17 October 2022
© 2022. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)
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References
- 1 Read RW, Holland GN, Rao NA. et al. Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 2001; 131 (05) 647-652 DOI: 10.1016/S0002-9394(01)00925-4.
- 2 Triplett JD, Buzzard KA, Lubomski M. et al. Immune-mediated conditions affecting the brain, eye and ear (BEE syndromes). J Neurol Neurosurg Psychiatry 2019; 90 (08) 882-894 DOI: 10.1136/jnnp-2018-319002.
- 3 Gu S, Liu Y, Song Z, Zi X, Deng H. Acute myelitis in a patient with vogt-koyanagi-harada disease: case report and review of the literature. J Clin Neurol 2013; 9 (01) 61-64 DOI: 10.3988/jcn.2013.9.1.61.
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