Immunmodulation mit Vitamin C

Zusammenfassung

Virale Infektionen führen zu einer überschießenden Immun- bzw. Entzündungsreaktion, die den Körper schädigt und die Abwehrlage reduziert. In der Folge steigt das Risiko für lebensbedrohliche Pneumonien durch normalerweise harmlose Pneumokokken-Stämme. Aus diesem Grunde ist eine immunmodulierende, antientzündliche Therapie notwendig. Vitamin C ist ein wichtiger körpereigener Immunmodulator, der bei Infekten in hohem Maß verbraucht wird. Er aktiviert die Immunabwehr (z. B. Interferon, NK-Zellaktivität) und schützt gleichzeitig vor überschießenden Entzündungen (Reduktion von IL1, TNF-α). Vitamin-C-Infusionen beheben schnell Mangelsituationen und lindern Symptome, indem sie vor oxidativem Stress schützen. Sie sind gut mit anderen naturheilkundlichen Therapien kombinierbar.

Abstract

Viral infections lead to excessive immune and inflammatory responses that harm healthy tissue and weaken the body’s immune status. As a consequence, there is increased risk of life-threatening pneumonia due to infection by usually-harmless pneumococci stains. Therefore, an immune-supportive and anti-inflammatory treatment is indicated. Vitamin C is a vital immunomodulatory micronutrient, the endogenous levels of which decrease during viral infections. It normally acts to stimulate immune defences (e. g. interferon, NK-cells) and protect against excessive inflammation (decreases levels of IL1, TNF-α and other pro-inflammatory factors). Intravenous vitamin C can quickly correct vitamin C deficiency states and alleviates symptoms, while combating oxidative stress and dampening inflammation. Vitamin C therapy is readily combined with other complementary and alternative therapies

Schlüsselwörter

Vitamin-C-Infusionen - Influenza - Pneumonien - Immunmodulation - Stress - Interferon - NK-Zellen - Interleukine - TNF-α

Keywords

Intravenous vitamin C - influenza - pneumonia - immunomodulation - stress - interferon - NK-cells - interleukins - TNF-α

• Literatur

• 1 Sharma-Chawla N, Sender V, Kershaw O. et al. Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation. Infection and Immunity 2016; 84: 3445-3457
• 2 Viebahn-Hänsler RLF, Fernández OLS, Fahmy Z. Ozone in Medicine: The low-dose ozone concept—guidelines and treatment strategies. Ozone: Science & Engineering 2012; 34: 408-424
• 3 Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A 1989; 86: 6377-6381
• 4 Du WD, Yuan ZR, Sun J. et al. Therapeutic efficacy of high-dose vitamin C on acute pancreatitis and its potential mechanisms. World J Gastroenterol 2003; 9: 2565-2569
• 5 Mikirova N, Casciari J, Rogers A. et al. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med 2012; 10: 189
• 6 Mikirova N, Rogers A, Casciari J. et al. Effect of high dose intravenous ascorbic acid on the level of inflammation in patients with rheumatoid arthritis. Modern Research in Inflammation 2012; 1: 26-32
• 7 Hagel AF, Layritz cm. Hagel WH. et al. Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases. Naunyn Schmiedebergs Arch Pharmacol 2013; 386 (09) 789-793
• 8 Kim H, Jang M, Kim Y. et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol 2016; 68: 406-420
• 9 Khameneh B, Fazly Bazzaz B, Amani A. et al. Combination of anti-tuberculosis drugs with vitamin C or NAC against different Staphylococcus aureus and Mycobacterium tuberculosis strains. Microbial Pathogenesis 2016; 93: 83-87
• 10 Douglas R, Hemila H, Chalker E. et al. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007; CD000980
• 11 Cai Y, Li YF, Tang LP. et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int 2015; DOI: 10.1155/2015/675149 0
• 12 Linster CL, Van Schaftingen E. Vitamin C. Biosynthesis, recycling and degradation in mammals. Febs J 2007; 274: 1-22
• 13 Levine M. New concepts in the biology and biochemistry of ascorbic acid. N Engl J Med 1986; 314: 892-902
• 14 Hume R, Weyers E. Changes in leucocyte ascorbic acid during the common cold. Scott Med J 1973; 18: 3-7
• 15 Goldschmidt MC. Reduced bactericidal activity in neutrophils from scorbutic animals and the effect of ascorbic acid on these target bacteria in vivo and in vitro. Am J Clin Nutr 1991; 54: 1214S-1220
• 16 Lunec J, Blake DR. The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis (RA). Free Radic Res Commun 1985; 1: 31-39
• 17 Shanmugasundaram K, Kumar S, Rajajee S. Excessive free radical generation in the blood of children suffering from asthma. Clinica Chimica Acta 2001; 1–2: 107-114
• 18 Chen JY, Chang CY, Feng PH. et al. Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain. Clin J Pain 2009; 25: 562-569
• 19 Jain SK, Pemberton PW, Smith A. et al. Oxidative stress in chronic hepatitis C: not just a feature of late stage disease. J Hepatol 2002; 36: 805-811
• 20 Unal M, Tamer L, Pata YS. et al. Serum levels of antioxidant vitamins, copper, zinc and magnesium in children with chronic rhinosinusitis. J Trace Elem Med Biol 2004; 18: 189-192
• 21 Nathens AB, Neff MJ, Jurkovich GJ. et al. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg 2002; 236: 814-822
• 22 Melhem A, Stern M, Shibolet O. et al. Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial. J Clin Gastroenterol 2005; 39: 737-742
• 23 Chen JY, Chu CC, So EC. et al. Treatment of postherpetic neuralgia with intravenous administration of vitamin C. Anesth Analg 2006; 103: 1616-1617
• 24 Schencking M, Vollbracht C, Weiss G. et al. Intravenous Vitamin C in the treatment of shingles: Results of a multicenter prospective cohort study. Med Sci Monit 2012; 18: CR215-224
• 25 Schmidt M. Die Vitamin C Hochdosis Infusions-Therapie bei Harninfekten und Harninkontinenz. Acta Biologica 2007; 1: 12-18
• 26 Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2013; 1: CD000980
• 27 Goldbaum JS. Vitamin C: the use of megascorbate therapy in general practice. A clinical experience. Australas Nurses J 1982; 11: 20-21
• 28 Gröber U. Orthomolekulare Medizin. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2002
• 29 Schencking M, Kraft K. Cantharidin patches and intravenous administration of vitamin C in the concomitant treatment of herpes zoster: a case report. Zhong Xi Yi Jie He Xue Bao 2011; 9: 410-413
• 30 Schencking M, Sandholzer H, Frese T. Intravenous administration of vitamin C in the treatment of herpetic neuralgia: two case reports. Med Sci Monit 2010; 16: CS58-61
• 31 Drolet M, Brisson M, Schmader KE. et al. The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective study. cmAJ 2010; 182: 1731-1736
• 32 PASCOE. PASCORBIN^® 7,5 g im Praxisalltag: Über 1.000 Ärzte und Heilpraktiker berichten über ihre Behandlungserfolge bei fast 200.000 Patienten. Ergebnisse einer retrospektiven Datenerhebung (2012). Gießen: Pascoe; 2012
• 33 Ely JT. Ascorbic acid role in containment of the world avian flu pandemic. Exp Biol Med (Maywood) 2007; 232: 847-851
• 34 PASCOE. Pascorbin: Die Vitamin-C-Hochdosis Infusionstherapie Wissenschaftliche Belege. 8. Aufl.. Gießen: Pascoe; 2016