Allgemein- und Viszeralchirurgie up2date 2017; 11(02): 197-208
DOI: 10.1055/s-0043-104953
Notfallchirurgie
Georg Thieme Verlag KG Stuttgart · New York

Das akute Abdomen auf der Intensivstation

Lars Fischer
,
Martin Apitz
,
Adrian Billeter
,
Stefan Hofer
,
Beat P. Müller-Stich
Further Information

Publication History

Publication Date:
19 April 2017 (online)

Das akute Abdomen ist stets ein Notfall und erfordert eine umgehende Abklärung. Gefragt ist insbesondere eine enge interdisziplinäre Zusammenarbeit zwischen Intensivpflegekräften, Anästhesisten, Chirurgen, Radiologen und Mikrobiologen.

Kernaussagen
  • Die Diagnose und die Therapie der Sepsis erfordert eine intensive und interdisziplinäre Zusammenarbeit zwischen Intensivpflege, Anästhesisten, Chirurgen, Radiologen und Mikrobiologen.

  • Das akute Abdomen in der Intensivtherapie erfordert zwingend eine unverzügliche Diagnostik und falls notwendig eine chirurgische Sanierung.

  • Bei Anzeichen einer Sepsis muss man frühzeitig mit der leitliniengerechten, antibiotischen und hämodynamischen Therapie beginnen. Patienten mit persistierend hohen postoperativen laborchemischen Entzündungswerten oder steigenden Entzündungswerten unter antibiotischer Therapie sollten frühzeitig einer Ursachendiagnostik mit Bildgebung (CT und Sonografie) und ggf. Exploration unterzogen werden.

  • Die sekundäre Peritonitis ist eine häufige Ursache der Sepsis bei chirurgischen Patienten. Zuerst sollte man daher operationsbedingte Komplikationen ausschließen. Hierzu ist eine frühzeitige interdisziplinäre Kommunikation mit den beteiligten Chirurgen zur Fokussuche und Fokussanierung dringend gefordert.

  • Die chirurgische Therapie zielt auf eine definitive Beseitigung der Sepsisursache mit primärem Bauchdeckenverschluss ab. Postoperativ ist der Patient auf ein abdominelles Kompartmentsyndrom oder eine persistierende Sepsis und Peritonitis zu überwachen. Mögliche Folge-Laparotomien und Re-Explorationen müssen frühzeitig eingeleitet werden.

 
  • Literatur

  • 1 Engel C, Brunkhorst FM, Bone HG. et al. Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med 2007; 33: 606-618
  • 2 Angus DC, Linde-Zwirble WT, Lidicker J. et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303-1310
  • 3 Ranieri VM, Thompson BT, Barie PS. et al. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012; 366: 2055-2064
  • 4 Lamme B, Boermeester MA, Belt EJT. et al. Mortality and morbidity of planned relaparotomy versus relaparotomy on demand for secondary peritonitis. Br J Surg 2004; 91: 1046-1054
  • 5 van Ruler O, Mahler CW, Boer KR. et al. Comparison of on-demand vs. planned relaparotomy strategy in patients with severe peritonitis: a randomized trial. JAMA 2007; 298: 865-872
  • 6 Dellinger RP, Levy MM, Rhodes A. et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41: 580-637
  • 7 Moore LJ, Moore FA. Early diagnosis and evidence-based care of surgical sepsis. J Intensive Care Med 2013; 28: 107-117
  • 8 Cardoso LT, Grion CM, Matsuo T. et al. Impact of delayed admission to intensive care units on mortality of critically ill patients: a cohort study. Crit Care 2011; 15: R28
  • 9 Kumar A, Roberts D, Wood KE. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Annals of Internal Medicine 2007; 147: 413
  • 10 de Dombal FT. The OMGE acute abdominal pain survey. Progress report, 1986. Scand J Gastroenterol Suppl 1988; 144: 35-42
  • 11 Gajic O, Urrutia LE, Sewani H. et al. Acute abdomen in the medical intensive care unit. Crit Care Med 2002; 30: 1187-1190
  • 12 Brewer BJ, Golden GT, Hitch DC. et al. Abdominal pain. An analysis of 1,000 consecutive cases in a University Hospital emergency room. Am J Surg 1976; 131: 219-223
  • 13 Grundmann RT, Petersen M, Lippert H. et al. Das akute (chirurgische) Abdomen – Epidemiologie, Diagnostik und allgemeine Prinzipien des Managements. Z Gastroenterol 2010; 48: 696-706
  • 14 Beyer K, Menges P, Kessler W. et al. Pathophysiology of peritonitis. Chirurg 2016; 87: 5-12
  • 15 Wittmann DH, Schein M, Condon RE. Management of secondary peritonitis. Ann Surg 1996; 224: 10-18
  • 16 Weiss G, Steffanie W, Lippert H. Die Peritonitis – Hauptursache schwerer Sepsis auf chirurgischer Intensivstation. Zentralbl Chir 2007; 132: 130-137
  • 17 Chavez-Tapia NC, Soares-Weiser K, Brezis M. et al. Antibiotics for spontaneous bacterial peritonitis in cirrhotic patients. Cochrane Database Syst Rev 2009; (01) CD002232
  • 18 Eckmann C. Antibiotikatherapie intraabdomineller Infektionen im Zeitalter der Multiresistenz. Chirurg 2016; 87: 26-33
  • 19 Seiler CA, Brügger L, Forssmann U. et al. Conservative surgical treatment of diffuse peritonitis. Surgery 2000; 127: 178-184
  • 20 Evans HL, Raymond DP, Pelletier SJ. et al. Tertiary peritonitis (recurrent diffuse or localized disease) is not an independent predictor of mortality in surgical patients with intraabdominal infection. Surg Infect (Larchmt) 2001; 2: 255-263 discussion 264–265
  • 21 Malangoni MA. Evaluation and management of tertiary peritonitis. Am Surg 2000; 66: 157-161
  • 22 Lamme B, Mahler CW, van Ruler O. et al. Clinical predictors of ongoing infection in secondary peritonitis: systematic review. World J Surg 2006; 30: 2170-2181
  • 23 Singer M, Deutschman CS, Seymour CW. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315: 801-810
  • 24 Welsch T, Frommhold K, Hinz U. et al. Persisting elevation of C-reactive protein after pancreatic resections can indicate developing inflammatory complications. Surgery 2008; 143: 20-28
  • 25 Ortega-Deballon P, Radais F, Facy O. et al. C-reactive protein is an early predictor of septic complications after elective colorectal surgery. World J Surg 2010; 34: 808-814
  • 26 Hochreiter M, Köhler T, Schweiger A. et al. Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial. Crit Care 2009; 13: R83
  • 27 Wacker C, Prkno A, Brunkhorst FM. et al. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis 2013; 13: 426-435
  • 28 Simon L, Gauvin F, Amre DK. et al. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: A systematic review and meta-analysis. Clin Infect Dis 2004; 39: 206-217
  • 29 Bader FG, Schröder M, Kujath P. et al. Diffuse postoperative peritonitis – value of diagnostic parameters and impact of early indication for relaparotomy. Eur J Med Res 2009; 14: 491-496
  • 30 Sartelli M, Viale P, Catena F. et al. 2013 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg 2013; 8: 3
  • 31 Doria AS, Moineddin R, Kellenberger CJ. et al. US or CT for Diagnosis of Appendicitis in Children and Adults? A Meta-Analysis. Radiology 2006; 241: 83-94
  • 32 Schreiber J, Nierhaus A, Vettorazzi E. et al. Rescue bedside laparotomy in the intensive care unit in patients too unstable for transport to the operating room. Crit Care 2014; 18: R123
  • 33 Hecker A, Uhle F, Schwandner T. et al. Diagnostics, therapy and outcome prediction in abdominal sepsis: current standards and future perspectives. Langenbecks Arch Surg 2014; 399: 11-22
  • 34 Champagne BJ, Darling RC, Daneshmand M. et al. Outcome of aggressive surveillance colonoscopy in ruptured abdominal aortic aneurysm. J Vasc Surg 2004; 39: 792-796
  • 35 Lin CC, Lee YC, Lee H. et al. Bedside colonoscopy for critically ill patients with acute lower gastrointestinal bleeding. Intensive Care Med 2005; 31: 743-746
  • 36 Church J, Kao J. Bedside colonoscopy in intensive care units: Indications, techniques, and outcomes. Surg Endosc 2014; 28: 2679-2682
  • 37 Anderson JL, Halperin JL, Albert N. et al. Management of Patients With Peripheral Artery Disease (Compilation of 2005 and 2011 ACCF/AHA Guideline Recommendations). J Am Coll Cardiol 2013; 61: 1555-1570
  • 38 Brower RG, Lanken PN, MacIntyre N. et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004; 351: 327-336
  • 39 ARDS Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308
  • 40 Solomkin JS, Mazuski JE, Bradley JS. et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 2010; 50: 133-164
  • 41 Bassetti M, Marchetti M, Chakrabarti A. et al. A research agenda on the management of intra-abdominal candidiasis: Results from a consensus of multinational experts. Intensive Care Med 2013; 39: 2092-2106
  • 42 de With K, Allerberger F, Amann S. et al. Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases. Infection 2016; 44: 395-439
  • 43 Cobos-Trigueros N, Solé M, Castro P. et al. Evaluation of a Mixing versus a Cycling Strategy of Antibiotic Use in Critically-Ill Medical Patients: Impact on Acquisition of Resistant Microorganisms and Clinical Outcomes. PLoS One 2016; 11: e0150274
  • 44 Hughes MG, Evans HL, Chong TW. et al. Effect of an intensive care unit rotating empiric antibiotic schedule on the development of hospital-acquired infections on the non-intensive care unit ward. Crit Care Med 2004; 32: 53-60
  • 45 Gruson D, Hilbert G, Vargas F. et al. Strategy of antibiotic rotation: Long-term effect on incidence and susceptibilities of Gram-negative bacilli responsible for ventilator-associated pneumonia. Crit Care Med 2003; 31: 1908-1914
  • 46 de Jong E, van Oers JA, Beishuizen A. et al. Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial. Lancet Infect Dis 2016; 16: 819-827
  • 47 Bouadma L, Luyt CE, Tubach F. et al. Use of procalcitonin to reduce patientsʼ exposure to antibiotics in intensive care units (PRORATA trial): A multicentre randomised controlled trial. Lancet 2010; 375: 463-474
  • 48 Prkno A, Wacker C, Brunkhorst FM. et al. Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock—a systematic review and meta-analysis. Crit Care 2013; 17: R291
  • 49 Marshall JC, Innes M. Intensive care unit management of intra-abdominal infection. Crit Care Med 2003; 31: 2228-2237
  • 50 Weber DG, Bendinelli C, Balogh ZJ. Damage control surgery for abdominal emergencies. Br J Surgery 2014; 101: e109-e118
  • 51 Strobel O, Werner J, Büchler MW. Chirurgische Therapie der Peritonitis. Chirurg 2011; 82: 242-248
  • 52 Polk HC, Fry DE. Radical peritoneal debridement for established peritonitis. The results of a prospective randomized clinical trial. Ann Surg 1980; 192: 350-355
  • 53 Malbrain ML, Cheatham ML, Kirkpatrick A. et al. Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions. Intensive Care Med 2006; 32: 1722-1732
  • 54 Cheatham ML, Malbrain ML, Kirkpatrick A. et al. Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations. Intensive Care Med 2007; 33: 951-962
  • 55 Atema JJ, Gans SL, Boermeester MA. Systematic review and meta-analysis of the open abdomen and temporary abdominal closure techniques in non-trauma Patients. World J Surg 2015; 39: 912-925
  • 56 Correa JC, Mejía DA, Duque N. et al. Managing the open abdomen: Negative pressure closure versus mesh-mediated fascial traction closure: a randomized trial. Hernia 2016; 20: 221-229
  • 57 Lamme B, Boermeester MA, Reitsma JB. et al. Meta-analysis of relaparotomy for secondary peritonitis. Br J Surg 2002; 89: 1516-1524
  • 58 Kirkpatrick AW, Roberts DJ, De Waele J. et al. Intra-abdominal hypertension and the abdominal compartment syndrome: Updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome. Intensive Care Med 2013; 39: 1190-1206