Volumenmanagement bei Sepsis und septischer Schock

Abstract

Sepsis and septic shock are common diseases with high mortality rates. Although volume therapy has been a central component of sepsis therapy for decades, the choice of optimal fluid and fluid intake is unclear. This paper summarizes findings on pathophysiology, clinical trial results, and current recommendations for optimal volume and fluid management in sepsis.

Sepsis und septischer Schock sind häufige Krankheitsbilder mit unverändert hoher Mortalität. Obwohl die Volumentherapie seit Jahrzehnten zentraler Bestandteil der Sepsistherapie ist, ist die Wahl der optimalen Flüssigkeit und Menge der Flüssigkeitszufuhr ungeklärt. Dieser Beitrag fasst Erkenntnisse zur Pathophysiologie, Ergebnisse klinischer Studien und aktuelle Empfehlungen zum optimalen Volumen- und Flüssigkeitsmanagement bei Sepsis zusammen.

Schlüsselwörter

Sepsis - Flüssigkeitsmanagement - septischer Schock - Organdysfunktion

Key words

sepsis - fluid management - septic shock - organ dysfunction

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