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Exp Clin Endocrinol Diabetes 2018; 126(04): 229-241
DOI: 10.1055/s-0043-110482
Article
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Hypoxia during Continuous and Intermittent Exercise on Glycaemic Control and Selected Markers of Vascular Function in Type 1 Diabetes

Barbara Hall
1   Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikolowska Street 72 A, Katowice, Poland.
,
Aleksandra Zebrowska
1   Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikolowska Street 72 A, Katowice, Poland.
,
Tomasz Kaminski
1   Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of Physical Education, Mikolowska Street 72 A, Katowice, Poland.
,
Arkadiusz Stanula
2   Department of Sports Theory, The Jerzy Kukuczka Academy of Physical Education, Mikolowska Street 72 A, Katowice, Poland.
,
Anna Robins
3   School of Health Sciences, University of Salford, Allerton Building, Frederick Road Campus, Salford, England.
› Author Affiliations
Further Information

Publication History

received 12 March 2017
revised 04 May 2017

accepted 04 May 2017

Publication Date:
19 September 2017 (online)

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Abstract

Objectives The aim of the study was to assess the effect of continuous and intermittent exercise in hypoxia on glycaemic control and selected markers of vascular function in patients with Type 1 diabetes (T1D).

Methods 12 patients suffering from T1D for 12.1±6.0 years and 12 healthy adults performed: continuous exercise (ExC) and intermittent exercise (ExInt) in normoxia and hypoxia (FiO₂=15.1%). Glycaemia and proangiogenic factors concentrations were measured at rest and immediately after exercise.

Results T1D patients’ glycaemia decreased in response to ExC (p<0.01) and ExInt (p<0.05) under hypoxic conditions. ExInt in normoxia (p<0.05) and hypoxia (p<0.05) reduced HIF-1α in the T1D group. A tendency for vascular endothelial growth factor to increase after ExInt in hypoxia (6.0±3.8 vs. 17.1±13.07 pg/mL) and a proinflammatory cytokine TNF-α level to decrease (33.2±19.1 vs. 25.1±14.4 pg/mL) was found in the same group.

Conclusions Combining exercise with hypoxia may allow more effective short-term glycaemic control in T1D. Intermittent exercise with hypoxia could stabilize the secretion of selected proangiogenic factors and reduce inflammation, potentially leading to improved vascular function.

 

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