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Dtsch Med Wochenschr 2018; 143(09): 643-650
DOI: 10.1055/s-0043-119958
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© Georg Thieme Verlag KG Stuttgart · New York

Multiresistente Bakterien: Antibiotikaverordnung und Reserveantibiotika

Multiresistant Bacteria – Antibiotic Prescription and Antibiotics of Last Resort
Winfried V. Kern
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Publication History

Publication Date:
23 April 2018 (online)

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Abstract

Ascertaining critical indications for antibiotics and rational prescribing can delay and minimize the spread of antibiotic resistance. Room for improvement lies in particular in a stricter indication, in shortening antibiotic treatment and in initiating more targeted therapies with narrow-spectrum drugs. Not all infections due to multidrug-resistant organisms require treatment with reserve drugs. Detailed susceptibility testing together with enhanced knowledge of pharmacokinetics and -dynamics are needed for adequate treatment decisions. There are some new drugs with interesting spectrum of activity in development. The problem of antimicrobial resistance in human medicine, however, must also be seen in the context of “One Health” interactions between various systems including environmental issues and food production.

Kritische Indikationen und rationale Verordnung können die weitere Ausbreitung von Antibiotikaresistenzen verzögern und minimieren. Potenzial liegt hier in einer strengeren Indikationsstellung bei Verschreibungen und einer Verkürzung der Therapiedauer – Infektionen durch multiresistente Erreger benötigen nicht immer eine Therapie mit Reserveantibiotika!

Schlüsselwörter

Antibiotika - Infektionskrankheiten - Multiresistenz - Reserveantibiotika

Key words

antibiotics - infectious diseases - multi-drug resistance - antibiotics of last resort
 

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