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Journal of Pediatric Neurology 2024; 22(01): 029-036
DOI: 10.1055/s-0043-1761620
Original Article

Outcome in Childhood Stroke: Comparing Functional Outcome by Modified Rankin Scale with Neurological Outcome by Pediatric Stroke Outcome Measure

Tatia Aprasidze 
1   Department of Neurology, David Tvildiani Medical University, Tbilisi, Georgia
2   Department of Neuroscience, M. Iashvili Children's Central Hospital, Tbilisi, Georgia
,
Teona Shatirishvili
1   Department of Neurology, David Tvildiani Medical University, Tbilisi, Georgia
2   Department of Neuroscience, M. Iashvili Children's Central Hospital, Tbilisi, Georgia
,
Gabriela Oesch
3   Division of Child Neurology, Department of Pediatrics, University Children's Hospital Bern, University of Bern, Bern, Switzerland
,
Giorgi Lomidze
4   Department of Neurology, European University, Tbilisi, Georgia
,
Nana Tatishvili
1   Department of Neurology, David Tvildiani Medical University, Tbilisi, Georgia
2   Department of Neuroscience, M. Iashvili Children's Central Hospital, Tbilisi, Georgia
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Abstract

Different scales are used as outcome predictors following arterial ischemic stroke (AIS) in children. Pediatric stroke outcome measure (PSOM) gives information about neurological deficits and function and modified Rankin scale (mRS) about functional outcome. Research examining the relationship between the two measures is scarce. The aim of this study is to correlate the two different scales and to get some information on the long course of outcomes according to these outcome measures. Sixty-one children with the diagnosis of AIS and normal neurodevelopment prior to stroke were investigated. Results of outcome measures (PSOM and mRS) from ≥ 2 years of follow-up were analyzed. Changes of neurological deficits (subcategories of PSOM) over time (discharge, 6 months, and ≥2 years) and prognostic impact on the outcome of the Pediatric National Institutes of Health Stroke Scale and etiology/risk factors are presented.

Cramer's V with a coefficient of 0.836 (df-1) indicates a strong association between dichotomized total PSOM and mRS scores. The correlation between the total scales was strong (rho = 0.983, p < 0.001). The correlation coefficient was highest for sensorimotor (rho = 0.949, p < 0.001), then for language (rho = 0.464, p < 0.001) and cognitive (rho = 0.363, p = 0.004) subscales. PSOM scores improved at 6 months compared to the discharge state in sensorimotor (p<0.001) and language (p<0.026) domains, however, there was no statistically significant difference between PSOM scores at 6 months and >2 years follow-up. There was no improvement in cognitive PSOM scores during the follow-up period.

There was a high concordance level between the two scales, illustrating that long-term neurological deficits after stroke are related to poor functional outcome. Significant improvement of sensorimotor and language function happened within the period from onset to 6 months of follow-up. Thus, early mobilization of appropriate rehabilitative therapy might improve the outcome. We conclude that both outcome classifications are applicable for assessing outcome after childhood AIS.

Keywords

outcome - pediatric stroke - functional outcome - PSOM - mRS

Ethical Statement

The research proposal has been reviewed and approved by M. Iashvili Children's Central Hospital and D. Tvildiani Medical University's Ethical Committee. Informed consent was obtained from each patient/patient's parents/guardian.




Publication History

Received: 28 September 2022

Accepted: 30 December 2022

Article published online:
10 February 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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