Methods for the Synthesis of 1-Indanones Containing a β-Quaternary Carbon Center

Abstract

This article traces the development of synthetic routes toward 1-indanones containing a β-quaternary carbon center. The recent advancement in the regio- and chemoselective formal (4+1) carbocyclization of chalcones with internal alkynes via rhodium(III) catalysis for the synthesis of 1-indanones is highlighted.

Key words

1-indanone - quaternary carbon - synthetic methods - enantioselective - rhodium catalysis

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