Tatsumi T,
Sasamoto K,
Matsumoto T,
Hirano R,
Oikawa K,
Nakano M,
Yoshida M,
Oisaki K,
*,
Kanai M.
*
The University of Tokyo and National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan
Practical N-to-C Peptide Synthesis with Minimal Protecting Groups.
Commun. Chem. 2023;
6: 231
Key words
N-to-C peptide elongation - atom economy - nonapeptide synthesis
Significance
With growing applications of peptides, the development of efficient and atom-economical methods for their synthesis is highly desirable. The authors have demonstrated a sequence peptide elongation using unprotected amino acids or peptides with low waste.
Comment
The peptide synthesis, which proceed by N-to-C elongation, is performed in an atom-economical way and the only wastes produced are water and elemental sulfur. Furthermore, the strategy could be applied for nonapeptide synthesis.
