Effects of Hemogram Parameters on Remission Durations in Self-Limited Epilepsy with Centrotemporal Spikes

Abstract

The hemogram parameters have been extensively discussed in numerous diseases, including epilepsy, for their diagnostic and prognostic values. We aimed to investigate the impact of hemogram parameters, namely, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) at the time of the first seizure on the remission durations of the patients with self-limited epilepsy with centrotemporal spikes (SeLECTS). This retrospective study was conducted on patients with SeLECTS with a minimum follow-up of 2 years. We assessed the hemogram parameters obtained from the venous blood samples collected from the patients upon admission. The duration of remission was categorized into two groups for further data analysis: those with a remission period less than 2 years and those with a remission period of more than 2 years. This study involved 122 patients with SeLECTS, of which 85% (n = 102) had remission durations of ≤2 years. The analysis revealed that patients with remission durations exceeding 2 years had a significantly higher median leukocyte (p = 0.009), neutrophil (p < 0.001), and platelet (p < 0.001) counts. Additionally, higher levels of NLR and PLR were observed in patients with longer-term remission (p < 0.001). However, there were no significant differences between the two groups in terms of lymphocyte count, monocyte count, mean platelet volume, or LMR. Leukocyte, neutrophil, platelet, NLR, and PLR counts have shown potential as predictive indicators of remission times in patients with SeLECTS. Neurologists can potentially find value in these easily accessible parameters when evaluating the future trajectory of patients with SeLECTS.

Keywords

epilepsy - hemogram - leukocyte count - rolandic epilepsy - self-limited epilepsy with centrotemporal spikes

Authors' Contributions

All the authors have made substantial contributions to the creation of the concept, literature search, writing and editing of the manuscript, analyses, and evaluation of the results. ÇG has been primarily involved in acquisition of the data. All the authors have seen the final version and given their consent for publication.

Publikationsverlauf

Eingereicht: 17. April 2023

Angenommen: 15. Mai 2023

Artikel online veröffentlicht:
19. Juni 2023

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