Markowicz MW,
Dembinski R.
*
Oakland University, Rochester, USA
Fluorous Coupling Reagents: Application of 2-Chloro-4,6-bis[(heptadecafluorononyl)oxy]-1,3,5-triazine
in Peptide Synthesis.
Synthesis 2004; 80-86
DOI:
10.1055/s-2003-42492
Key words
2-chloro-4,6-bis[(heptadecafluoro-nonyl)oxy]-1,3,5-triazine - peptide synthesis -
fluorous coupling reagents
Significance
Development of eco-friendly, cost-effective, and practically easy coupling reagents
for peptide synthesis is a highly demanding area of peptide drugs discovery. In this
study, the authors invented 2-chloro-4,6-bis[(heptadecafluoro-nonyl)oxy]-1,3,5-triazine
as an efficient coupling reagent for the synthesis of various peptides.
Comment
Various peptides were synthesized by the coupling between N-benzyloxycarbonyl amino acids and amino acid methyl esters with the help of 2-chloro-4,6-bis[(heptadecafluorononyl)oxy]-1,3,5-triazine.
The protocol is practically simple and suitable for the synthesis of peptides having
sterically hindered α,α-disubstituted amino acids.
