Electron-Rich Triaryl Phosphine Mediated Electrochemical Synthesis of Peptides

Key words

electrochemical synthesis - triaryl phosphine - oligopeptides

Significance

Electrochemical peptide synthesis received considerable attention in peptide chemistry. The authors reported the synthesis of peptides using electron-rich triaryl phosphine under electrochemical conditions. The methodology was examined for a broad range of substrates including ­oligopeptides.

Comment

The authors developed an improved electrochemical peptide synthesis method using an electron-rich triaryl phosphine that is effective for sterically hindered amino acids and challenging peptides like Rapastinel and Bradykinin. ¹⁸O-Labeling experiments suggested the suppression of side reactions, by enabling efficient peptide coupling. This advancement will drive the development of novel peptide synthesis and more efficient ­synthetic systems for highly hindered amino acids.