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Synthesis 2024; 56(24): 3923-3928
DOI: 10.1055/s-0043-1775414
DOI: 10.1055/s-0043-1775414
paper
Special Topic Dedicated to Prof. Erick Carreira
Olefination of Activated Alkyl Halides with Phosphonium Salts
The European Research Council (Shuttle Cat, Project ID: 757608), ETH Zürich, and the FCI (scholarships to S.R. and C.L.B.) are acknowledged for funding of this work.
Dedicated to Prof. Erick M. Carreira on the occasion of his 60th birthday.
Abstract
A base-promoted olefination reaction between alkylphosphonium salts and activated alkyl halides has been developed. The products were obtained in excellent E-selectivity. In contrast to most other olefination reactions of phosphonium salts, the reaction yields triphenylphosphine as the main by-product, which can be directly reused in the formation of new phosphonium salts.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775414.
- Supporting Information
Publication History
Received: 03 July 2024
Accepted after revision: 08 October 2024
Article published online:
07 November 2024
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