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Clin Colon Rectal Surg
DOI: 10.1055/s-0044-1787826
Review Article

Systemic Therapy for Metastatic Colon Cancer: New Frontiers

Yoanna S. Pumpalova
1   Division of Hematology and Oncology, Department of Internal Medicine, Columbia University Irving Medical Center, New York, New York
› Author Affiliations Funding The author declares stock ownership in Pfizer, honoraria from Janssen, and participation on the advisory board of BMS.
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Abstract

We have made steady gains in improving overall survival in patients with metastatic, unresectable, colon cancer in the last 5 to 10 years. The backbone of systemic treatment for most patients remains combination chemotherapy, but the field is becoming increasingly biomarker driven, with exciting new targeted therapies on the horizon. This review is organized in sections corresponding to currently relevant biomarkers in colon cancer and will summarize first-, second-, and third-line standard of care for metastatic, unresectable, colon cancer. The last section is intended to introduce the reader to promising agents and novel therapeutic strategies currently under investigation.

Keywords

metastatic colon cancer - systemic therapy - investigational agents


Publication History

Article published online:
25 June 2024

© 2024. Thieme. All rights reserved.

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