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DOI: 10.1055/s-0044-1791227
Altered Mental Status and Delirium in Pediatric Patients
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Abstract
Mental status is the collection of an individual's consciousness, perception, emotion, memory, and cognition at a particular point in time, which is inferred by the clinician through careful observation and interaction. The pediatric mental status assessment must be approached with an understanding of cognitive, language, and psychosocial development. Alterations must then be comprehensively and clearly described. Delirium is a phenotypic diagnosis with a specific set of criteria in the DSM and is a serious neurocognitive disorder caused by physiologic changes due to illness, injury, toxins, medications, and/or substances. Recognition of delirium in children is improved by monitoring of predisposing risks and precipitating factors, as well as the regular use of validated pediatric screening tools. Management of delirium is focused on treatment of the underlying etiology, prevention of iatrogenic deliriogenic factors, and patient safety.
Publication History
Article published online:
30 September 2024
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References
- 1 Erkkinen MG, Berkowitz AL. A clinical approach to diagnosing encephalopathy. Am J Med 2019; 132 (10) 1142-1147
- 2 Slooter AJC, Otte WM, Devlin JW. et al. Updated nomenclature of delirium and acute encephalopathy: statement of ten societies. Intensive Care Med 2020; 46 (05) 1020-1022
- 3 American Psychiatric Association. Diagnostic and Statistical Manual of mental disorders: DSM-5-TR. Fifth edition,. text revision. American Psychiatric Association Publishing; 2022. :lxix, 1050pp
- 4 Laureys S, Tononi G. The Neurology of Consciousness: Cognitive Neuroscience and Neuropathology. 1st ed. Academic Press/Elsevier; 2009
- 5 Swaiman KF, Ashwal S, Ferriero DM. et al. Swaiman's Pediatric Neurology: Principles and Practice. 6th ed. Pediatric Neurology. Elsevier; 2018
- 6 Abecassis TAD. Mental Status Examination (MSE). Accessed September 3, 2024 at: https://primarycare.ementalhealth.ca/index.php?m=fpArticle&ID=26974
- 7 Caplan R, Bursch B. How Many More Questions?: Techniques for Clinical Interviews of Young Medically Ill Children. Oxford University Press; 2013. :xvii, 324pp
- 8 Turkel SB. Pediatric delirium: recognition, management, and outcome. Curr Psychiatry Rep 2017; 19 (12) 101
- 9 Siegel EJ, Traube C. Pediatric delirium: epidemiology and outcomes. Curr Opin Pediatr 2020; 32 (06) 743-749
- 10 Traube C, Silver G, Reeder RW. et al. Delirium in critically ill children: an international point prevalence study. Crit Care Med 2017; 45 (04) 584-590
- 11 Traube C, Silver G, Gerber LM. et al. Delirium and mortality in critically ill children: epidemiology and outcomes of pediatric delirium. Crit Care Med 2017; 45 (05) 891-898
- 12 Traube C, Greenwald BM. “The times they are a-changin”: universal delirium screening in pediatric critical care. Pediatr Crit Care Med 2017; 18 (06) 594-595
- 13 Traube C, Silver G, Kearney J. et al. Cornell assessment of pediatric delirium: a valid, rapid, observational tool for screening delirium in the PICU*. Crit Care Med 2014; 42 (03) 656-663
- 14 Alvarez RV, Palmer C, Czaja AS. et al. Delirium is a common and early finding in patients in the pediatric cardiac intensive care unit. J Pediatr 2018; 195: 206-212
- 15 Meyburg J, Dill ML, Traube C, Silver G, von Haken R. Patterns of postoperative delirium in children. Pediatr Crit Care Med 2017; 18 (02) 128-133
- 16 Simone S, Edwards S, Lardieri A. et al. Implementation of an ICU bundle: an interprofessional quality improvement project to enhance delirium management and monitor delirium prevalence in a single PICU. Pediatr Crit Care Med 2017; 18 (06) 531-540
- 17 Smith HA, Boyd J, Fuchs DC. et al. Diagnosing delirium in critically ill children: validity and reliability of the pediatric confusion assessment method for the intensive care unit. Crit Care Med 2011; 39 (01) 150-157
- 18 Smith HA, Brink E, Fuchs DC, Ely EW, Pandharipande PP. Pediatric delirium: monitoring and management in the pediatric intensive care unit. Pediatr Clin North Am 2013; 60 (03) 741-760
- 19 Smith HAB, Gangopadhyay M, Goben CM. et al. The preschool confusion assessment method for the ICU: valid and reliable delirium monitoring for critically ill infants and children. Crit Care Med 2016; 44 (03) 592-600
- 20 de Castro REV, Prata-Barbosa A, de Magalhães-Barbosa MC, Cunha AJLAD, Cheniaux E, Smith HAB. Validity and reliability of the Brazilian Portuguese version of the pediatric confusion assessment method for the ICU. Pediatr Crit Care Med 2020; 21 (01) e39-e46
- 21 Canter MO, Tanguturi YC, Ellen Wilson J. et al. Prospective validation of the preschool confusion assessment method for the ICU to screen for delirium in infants less than 6 months old. Crit Care Med 2021; 49 (10) e902-e909
- 22 Smith HAB, Besunder JB, Betters KA. et al. 2022 Society of Critical Care Medicine Clinical Practice Guidelines on prevention and management of pain, agitation, neuromuscular blockade, and delirium in critically ill pediatric patients with consideration of the ICU environment and early mobility. Pediatr Crit Care Med 2022; 23 (02) e74-e110
- 23 Smith HAB, Gangopadhyay M, Goben CM. et al. Delirium and benzodiazepines associated with prolonged ICU stay in critically ill infants and young children. Crit Care Med 2017; 45 (09) 1427-1435
- 24 Patel AK, Biagas KV, Clarke EC. et al. Delirium in children after cardiac bypass surgery. Pediatr Crit Care Med 2017; 18 (02) 165-171
- 25 Silver G, Traube C, Gerber LM. et al. Pediatric delirium and associated risk factors: a single-center prospective observational study. Pediatr Crit Care Med 2015; 16 (04) 303-309
- 26 Smeets IA, Tan EY, Vossen HG. et al. Prolonged stay at the paediatric intensive care unit associated with paediatric delirium. Eur Child Adolesc Psychiatry 2010; 19 (04) 389-393
- 27 Dervan LA, Di Gennaro JL, Farris RWD, Watson RS. Delirium in a tertiary PICU: risk factors and outcomes. Pediatr Crit Care Med 2020; 21 (01) 21-32
- 28 Silver G, Doyle H, Hegel E. et al. Association between pediatric delirium and quality of life after discharge. Crit Care Med 2020; 48 (12) 1829-1834
- 29 Traube C, Ariagno S, Thau F. et al. Delirium in hospitalized children with cancer: incidence and associated risk factors. J Pediatr 2017; 191: 212-217
- 30 Blackman I, De Armas R, Padilla S. et al. 845: Benzodiazepines and pediatric delirium: Is there any safe dose?. Crit Care Med 2024; 52 (01) S395
- 31 Winsnes K, Sochacki P, Eriksson C. et al. Delirium in the pediatric hematology, oncology, and bone marrow transplant population. Pediatr Blood Cancer 2019; 66 (06) e27640
- 32 Lyu J, Jia Y, Yan M. et al. Risk factors for postoperative delirium in children with congenital heart disease: a prospective nested case-control study. CJCP 2022; 24 (03) 232-239
- 33 Mody K, Kaur S, Mauer EA. et al. Benzodiazepines and development of delirium in critically ill children: estimating the causal effect. Crit Care Med 2018; 46 (09) 1486-1491
- 34 Patel AK, Bell MJ, Traube C. Delirium in pediatric critical care. Pediatr Clin North Am 2017; 64 (05) 1117-1132
- 35 Fuller G. Neurological Examination Made Easy. 4th ed. Churchill Livingstone; 2008. :vi, 220pp
- 36 Hartman ME, Williams CN, Hall TA, Bosworth CC, Piantino JA. Post-intensive-care syndrome for the pediatric neurologist. Pediatr Neurol 2020; 108: 47-53
- 37 Dow BL, Kenardy JA, Long DA, Le Brocque RM. Cognitive/affective factors are associated with children's acute posttraumatic stress following pediatric intensive care. Psychol Trauma 2019; 11 (01) 55-63
- 38 Takaoka K, Takata T. Catatonia in childhood and adolescence. Psychiatry Clin Neurosci 2003; 57 (02) 129-137
- 39 Silver G, Traube C, Kearney J. et al. Detecting pediatric delirium: development of a rapid observational assessment tool. Intensive Care Med 2012; 38 (06) 1025-1031
- 40 Madden M, Smith H, Williams S. Delirium. . In: Adeyinka A, Irving S, Rehder K. eds. Current Concepts in Pediatric Critical Care. Society of Critical Care Medicine; 2025
- 41 Ely EW, Margolin R, Francis J. et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med 2001; 29 (07) 1370-1379
- 42 Wilson JE, Mart MF, Cunningham C. et al. Delirium. Nat Rev Dis Primers 2020; 6 (01) 90
- 43 Maldonado JR. Delirium pathophysiology: an updated hypothesis of the etiology of acute brain failure. Int J Geriatr Psychiatry 2018; 33 (11) 1428-1457
- 44 Inouye SK, Westendorp RG, Saczynski JS. Delirium in elderly people. Lancet 2014; 383 (9920) 911-922
- 45 Gil Mayo D, Sanabria Carretero P, Gajate Martin L, Alonso Calderón J, Hernández Oliveros F, Gomez Rojo M. Parental presence during induction of anesthesia improves compliance of the child and reduces emergence delirium. Eur J Pediatr Surg 2022; 32 (04) 346-351
- 46 Cai A, Cai X. Toxin-induced acute delirium. Neurol Clin 2020; 38 (04) 781-798
- 47 Schifano F, Chiappini S, Corkery JM, Guirguis A. An insight into Z-drug abuse and dependence: an examination of reports to the European Medicines Agency Database of suspected adverse drug reactions. Int J Neuropsychopharmacol 2019; 22 (04) 270-277
- 48 FDA Drug Safety Podcast. FDA warns about serious problems with high doses of the allergy medicine diphenhydramine (Benadryl). U.S. Food and Drug Administration. Accessed July 1, 2024 at: https://www.fda.gov/drugs/fda-drug-safety-podcasts/fda-warns-about-serious-problems-high-doses-allergy-medicine-diphenhydramine-benadryl#:~:text=On%20September%2024%2C%202020%20FDA,%2C%20coma%2C%20or%20even%20death
- 49 Su MK. Anticholinergic poisoning. In: Connor RF. ed. UpToDate. Wolters Kluwer; . Accessed March 8, 2024 at: https://www.uptodate.com/contents/anticholinergic-poisoning
- 50 Turkel SB, Hanft A. The pharmacologic management of delirium in children and adolescents. Paediatr Drugs 2014; 16 (04) 267-274
- 51 Capino AC, Thomas AN, Baylor S, Hughes KM, Miller JL, Johnson PN. Antipsychotic use in the prevention and treatment of intensive care unit delirium in pediatric patients. J Pediatr Pharmacol Ther 2020; 25 (02) 81-95
- 52 Hassinger AB, Afzal S, Rauth M, Breuer RK. Pediatric intensive care unit related sleep and circadian dysregulation: a focused review. Semin Pediatr Neurol 2023; 48: 101077
- 53 Kudchadkar SR, Aljohani OA, Punjabi NM. Sleep of critically ill children in the pediatric intensive care unit: a systematic review. Sleep Med Rev 2014; 18 (02) 103-110
- 54 Calandriello A, Tylka JC, Patwari PP. Sleep and delirium in pediatric critical illness: What is the relationship?. Med Sci (Basel) 2018; 6 (04) 90
- 55 Singla L, Mathew PJ, Jain A, Yaddanapudi S, Peters NJ. Oral melatonin as part of multimodal anxiolysis decreases emergence delirium in children whereas midazolam does not: a randomised, double-blind, placebo-controlled study. Eur J Anaesthesiol 2021; 38 (11) 1130-1137
- 56 Garioud ALB, Andersen LPK, Jensen AKG. et al. Intravenous MELAtonin for prevention of Postoperative Agitation and Emergence Delirium in children (MELA-PAED): a protocol and statistical analysis plan for a randomized clinical trial. Acta Anaesthesiol Scand 2024; 68 (02) 280-286
- 57 Chomat MR, Said AS, Mann JL, Wallendorf M, Bickhaus A, Figueroa M. Changes in sedation practices in association with delirium screening in infants after cardiopulmonary bypass. Pediatr Cardiol 2021; 42 (06) 1334-1340
- 58 Wang X, Deng Q, Liu B, Yu X. Preventing emergence agitation using ancillary drugs with sevoflurane for pediatric anesthesia: a network meta-analysis. Mol Neurobiol 2017; 54 (09) 7312-7326
- 59 Hayden JC, Breatnach C, Doherty DR. et al. Efficacy of α2-agonists for sedation in pediatric critical care: a systematic review. Pediatr Crit Care Med 2016; 17 (02) e66-e75
- 60 Ávila-Alzate JA, Gómez-Salgado J, Romero-Martín M, Martínez-Isasi S, Navarro-Abal Y, Fernández-García D. Assessment and treatment of the withdrawal syndrome in paediatric intensive care units: systematic review. Medicine (Baltimore) 2020; 99 (05) e18502
- 61 Solodiuk JC, Sweet E, Greco C. et al. Weaning dexmedetomidine in non-ICU areas: an implementation effort. Pediatr Crit Care Med 2022; 23 (05) 353-360
- 62 Franck LS, Harris SK, Soetenga DJ, Amling JK, Curley MA. The Withdrawal Assessment Tool-1 (WAT-1): an assessment instrument for monitoring opioid and benzodiazepine withdrawal symptoms in pediatric patients. Pediatr Crit Care Med 2008; 9 (06) 573-580
- 63 Alcohol use disorder (AUD) in the United States: age groups and demographic characteristics. National Institute on Alcohol Abuse and Alcoholism. Accessed January 29, 2024 at: https://www.niaaa.nih.gov/alcohols-effects-health/alcohol-topics/alcohol-facts-and-statistics/alcohol-use-disorder-aud-united-states-age-groups-and-demographic-characteristics
- 64 Boyer E. Serotonin syndrome (serotonin toxicity). In: Ganetsky M. , ed. UpToDate. 2023
- 65 Pedavally S, Fugate JE, Rabinstein AA. Serotonin syndrome in the intensive care unit: clinical presentations and precipitating medications. Neurocrit Care 2014; 21 (01) 108-113
- 66 Heckers S, Walther S. Catatonia. N Engl J Med 2023; 389 (19) 1797-1802
- 67 Hauptman AJ, Benjamin S. The differential diagnosis and treatment of catatonia in children and adolescents. Harv Rev Psychiatry 2016; 24 (06) 379-395
- 68 Bush G, Fink M, Petrides G, Dowling F, Francis A. Catatonia. II. Treatment with lorazepam and electroconvulsive therapy. Acta Psychiatr Scand 1996; 93 (02) 137-143
- 69 Rogers JP, Oldham MA, Fricchione G. et al. Evidence-based consensus guidelines for the management of catatonia: recommendations from the British Association for Psychopharmacology. J Psychopharmacol 2023; 37 (04) 327-369
- 70 Wilson JE, Carlson R, Duggan MC. et al; Delirium and Catatonia (DeCat) Prospective Cohort Investigation. Delirium and catatonia in critically ill patients: the delirium and catatonia prospective cohort investigation. Crit Care Med 2017; 45 (11) 1837-1844
- 71 Bush G, Fink M, Petrides G, Dowling F, Francis A, Catatonia I. Rating scale and standardized examination. Acta Psychiatr Scand 1996; 93 (02) 129-136
- 72 Benarous X, Consoli A, Raffin M. et al. Validation of the Pediatric Catatonia Rating Scale (PCRS). Schizophr Res 2016; 176 (2-3): 378-386
- 73 Mancuso CE, Tanzi MG, Gabay M. Paradoxical reactions to benzodiazepines: literature review and treatment options. Pharmacotherapy 2004; 24 (09) 1177-1185
- 74 Marrosu F, Marrosu G, Rachel MG, Biggio G. Paradoxical reactions elicited by diazepam in children with classic autism. Funct Neurol 1987; 2 (03) 355-361
- 75 Sanders RD, Gillig PM. Extrapyramidal examinations in psychiatry. Innov Clin Neurosci 2012; 9 (7-8): 10-16
- 76 Schipper S, Riederer F, Sándor PS, Gantenbein AR. Acute confusional migraine: our knowledge to date. Expert Rev Neurother 2012; 12 (03) 307-314
- 77 Pina Garza E. Fenichel's Clinical Pediatric Neurology. 8th ed. Elsevier: 2019
- 78 Rose CR, Chatton JY. Astrocyte sodium signaling and neuro-metabolic coupling in the brain. Neuroscience 2016; 323: 121-134
- 79 Piaget J. The Origins of Intelligence in Children. International Universities Press; 1952