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Clin Colon Rectal Surg
DOI: 10.1055/s-0044-1801380
Review Article

Segmental versus Extended Resection for Colon Cancer in Lynch's Syndrome

Jared R. Hendren
1   Department of Colon and Rectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio
2   Sanford R. Weiss, M.D. Center for Hereditary Colorectal Neoplasia, Cleveland Clinic Foundation, Cleveland, Ohio
,
Josh Sommovilla
1   Department of Colon and Rectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, Ohio
2   Sanford R. Weiss, M.D. Center for Hereditary Colorectal Neoplasia, Cleveland Clinic Foundation, Cleveland, Ohio
› Institutsangaben Funding None.
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Abstract

Lynch's syndrome is a common cause of hereditary colorectal cancer (CRC), resulting in higher risk of CRC and development of subsequent, metachronous CRC (mCRC). Beyond treating the primary cancer, surgeons and patients must decide on whether performing an extended colectomy, to reduce the risk of mCRC, is worth the change in function that comes with the larger operation. Considerations include likelihood for mCRC, morbidity and quality of life after resection, impact of pathogenic variant, and certain other cancer risk reduction options. The contemporary evidence to guide these decisions is reviewed herein.

Keywords

colon cancer - Lynch's syndrome - mismatch repair - colectomy - cancer surveillance


Publikationsverlauf

Artikel online veröffentlicht:
10. Januar 2025

© 2025. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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