Semin intervent Radiol
DOI: 10.1055/s-0045-1806723
Review Article

Anatomical Considerations for Biliary Interventions: Navigating Challenging Cases

Alex Wallace
1   Department of Radiology, Diagnostic and Interventional Radiology, Mayo Clinic Arizona, Phoenix, Arizona
,
Daniel Crawford
1   Department of Radiology, Diagnostic and Interventional Radiology, Mayo Clinic Arizona, Phoenix, Arizona
,
Merve Ozen
1   Department of Radiology, Diagnostic and Interventional Radiology, Mayo Clinic Arizona, Phoenix, Arizona
,
Indravadan Patel
1   Department of Radiology, Diagnostic and Interventional Radiology, Mayo Clinic Arizona, Phoenix, Arizona
› Author Affiliations

Abstract

A thorough understanding of normal biliary anatomy, common variants, and surgically altered anatomy is essential for the success of biliary interventions. Variations in biliary anatomy are seen in up to 40% of patients and frequently influence procedural planning and outcomes. This review highlights classical biliary anatomy, its common variations, and the challenges posed by surgical modifications, such as those encountered after cholecystectomy, liver resection, or biliary reconstructions. Case-based examples are used to explore the implications of these variations and modifications on interventional approaches, including the management of bile leaks, strictures, and complex obstructions. Strategies incorporating advanced imaging and procedural techniques, such as rendezvous interventions, are discussed to address complications and optimize outcomes. This article provides a practical framework for interventional radiologists to navigate challenging biliary cases with confidence and precision.



Publication History

Article published online:
10 April 2025

© 2025. Thieme. All rights reserved.

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  • References

  • 1 Aguiar JA, Riaz A, Thornburg B. Biliary anatomy. Semin Intervent Radiol 2021; 38 (03) 251-254
  • 2 Sibulesky L. Normal liver anatomy. Clin Liver Dis (Hoboken) 2013; 2 (Suppl. 01) S1-S3
  • 3 Standring S, Gray H. Eds. Gray's Anatomy: The Anatomical Basis of Clinical Practice. Forty-second ed. Elsevier; 2021
  • 4 Pitt HA, Nakeeb A. Bile secretion and pathophysiology of biliary tract obstruction. In: Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set. Elsevier; 2017: 123-132.e1
  • 5 Strazzabosco M, Fabris L. Functional anatomy of normal bile ducts. Anat Rec (Hoboken) 2008; 291 (06) 653-660
  • 6 Roskams TA, Theise ND, Balabaud C. et al. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology 2004; 39 (06) 1739-1745
  • 7 Keplinger KM, Bloomston M. Anatomy and embryology of the biliary tract. Surg Clin North Am 2014; 94 (02) 203-217
  • 8 Castaing D. Surgical anatomy of the biliary tract. HPB (Oxford) 2008; 10 (02) 72-76
  • 9 Ellis H, Mahadevan V. Clinical Anatomy: Applied Anatomy for Students and Junior Doctors. Fourteenth ed.. Wiley-Blackwell; 2019
  • 10 Janssen BV, van Laarhoven S, Elshaer M. et al. Comprehensive classification of anatomical variants of the main biliary ducts. Br J Surg 2021; 108 (05) 458-462
  • 11 Schnelldorfer T, Sarr MG, Adams DB. What is the duct of Luschka? A systematic review. J Gastrointest Surg 2012; 16 (03) 656-662
  • 12 Karaliotas CC, Broelsch CE, Habib NA. Liver and Biliary Tract Surgery: Embryological Anatomy to 3D-Imaging and Transplant Innovations. Springer Vienna Springer e-books; 2006
  • 13 Mortelé KJ, Rocha TC, Streeter JL, Taylor AJ. Multimodality imaging of pancreatic and biliary congenital anomalies. Radiographics 2006; 26 (03) 715-731
  • 14 Losanoff JE, Jones JW, Richman BW, Rangnekar NJ. Hepaticocystic duct: a rare anomaly of the extrahepatic biliary system. Clin Anat 2002; 15 (04) 314-315
  • 15 Gündüz N, Doğan MB, Alacagöz M, Yağbasan M, Orhan Söylemez UP, Atalay B. Anatomical variations of cystic duct insertion and their relationship with choledocholithiasis: an MRCP study. Egypt J Radiol Nucl Med 2021; 52 (01) 202
  • 16 Fujiwara K, Hiraka K, Shindo K. et al. Variations in the cystic duct: frequency and the relationship among insertion sides and heights on the bile duct. Surg Radiol Anat 2024; 46 (02) 223-230
  • 17 Camacho JC, Brody LA, Covey AM. Treatment of malignant bile duct obstruction: what the interventional radiologist needs to know. Semin Intervent Radiol 2021; 38 (03) 300-308
  • 18 Jang S, Stevens T, Parsi M. et al. Association of covered metallic stents with cholecystitis and stent migration in malignant biliary stricture. Gastrointest Endosc 2018; 87 (04) 1061-1070
  • 19 vanSonnenberg E, Mueller PR. Management of choledocholithiasis: interventional radiologists continue to push the envelope. Radiology 2021; 300 (02) 479-480
  • 20 Hersey N, Goode SD, Peck RJ, Lee F. Stenting of the cystic duct in benign disease: a definitive treatment for the elderly and unwell. Cardiovasc Intervent Radiol 2015; 38 (04) 964-970
  • 21 Lee TY, Kim JW, Shim DJ, Kim D, Yoon YC, Lee EW. Percutaneous cholecystoduodenal stent as a definite treatment for acute cholecystitis in elderly or comorbid patients: a bicentric retrospective study. Diagn Interv Radiol 2023; 29 (02) 367-372
  • 22 Koo SS, Krishnan RJ, Ishikawa K. et al. Subtotal vs total cholecystectomy for difficult gallbladders: a systematic review and meta-analysis. Am J Surg 2024; 229: 145-150
  • 23 Elshaer M, Gravante G, Thomas K, Sorge R, Al-Hamali S, Ebdewi H. Subtotal cholecystectomy for “difficult gallbladders”: systematic review and meta-analysis. JAMA Surg 2015; 150 (02) 159-168
  • 24 Dimick JB, Cowan Jr JA, Knol JA, Upchurch Jr GR. Hepatic resection in the United States: indications, outcomes, and hospital procedural volumes from a nationally representative database. Arch Surg 2003; 138 (02) 185-191
  • 25 Tripke V, Sommer N. An update on liver surgery - a new terminology and modern techniques. Innov Surg Sci 2024; 8 (04) 197-201
  • 26 Strasberg SM, Belghiti J, Clavien PA. et al. The Brisbane 2000 terminology of liver anatomy and resections. HPB (Oxford) 2000; 2 (03) 333-339
  • 27 Koch M, Garden OJ, Padbury R. et al. Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery. Surgery 2011; 149 (05) 680-688
  • 28 Martin AN, Narayanan S, Turrentine FE. et al. Clinical factors and postoperative impact of bile leak after liver resection. J Gastrointest Surg 2018; 22 (04) 661-667
  • 29 Capussotti L, Ferrero A, Viganò L, Sgotto E, Muratore A, Polastri R. Bile leakage and liver resection: Where is the risk?. Arch Surg 2006; 141 (07) 690-694 , discussion 695
  • 30 Franco J. Biliary complications in liver transplant recipients. Curr Gastroenterol Rep 2005; 7 (02) 160-164
  • 31 Neuhaus P, Blumhardt G, Bechstein WO, Steffen R, Platz KP, Keck H. Technique and results of biliary reconstruction using side-to-side choledochocholedochostomy in 300 orthotopic liver transplants. Ann Surg 1994; 219 (04) 426-434
  • 32 Mercado MA, Vilatoba M, Contreras A. et al. Iatrogenic bile duct injury with loss of confluence. World J Gastrointest Surg 2015; 7 (10) 254-260
  • 33 Riaz A, Entezari P, Ganger D. et al. Percutaneous access of the modified Hutson loop for retrograde cholangiography, endoscopy, and biliary interventions. J Vasc Interv Radiol 2020; 31 (12) 2113-2120.e1
  • 34 Ruas JN, Mendonça EQ, Lenz L. et al. Correlation between liver volume drainage and clinical success after endoscopic biliary drainage of hilar malignant obstruction. Clinics (Sao Paulo) 2024; 80: 100540
  • 35 Vienne A, Hobeika E, Gouya H. et al. Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment. Gastrointest Endosc 2010; 72 (04) 728-735
  • 36 Kim SH, Zangan SM. Percutaneous transhepatic biliary drainage complicated by bilothorax. Semin Intervent Radiol 2015; 32 (01) 54-56
  • 37 Sano A, Yotsumoto T. Bilothorax as a complication of percutaneous transhepatic biliary drainage. Asian Cardiovasc Thorac Ann 2016; 24 (01) 101-103
  • 38 Lee MT, Hsi SC, Hu P, Liu KY. Biliopleural fistula: a rare complication of percutaneous transhepatic gallbladder drainage. World J Gastroenterol 2007; 13 (23) 3268-3270