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Semin Reprod Med 2000; 18(3): 289-298
DOI: 10.1055/s-2000-12566
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Glycodelin: A Pane in the Implantation Window

Michael D. Mueller1 , Jean-Louis Vigne1 , Christian Vaisse2 , Robert N. Taylor1
  • 1Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences
  • 2Metabolic Research Unit, Department of Medicine, University of California, San Francisco School of Medicine, San Francisco, California
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Publication History

Publication Date:
31 December 2000 (online)

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ABSTRACT

Glycodelin is an endometrial protein with proposed immunomodulatory activity during human embryonic nidation. In this review we describe the effects of ovarian hormones on glycodelin transcription, synthesis, and secretion by human epithelial cells and focus on the importance of glycodelin in implantation. We demonstrate that glycodelin transcription, synthesis, and secretion by human epithelial cells are stimulated by progestins and antiprogestins but not by estrogen. Sequences localized within a 403-base-pair region flanking the 5′ human glycodelin gene promoter appear to be responsible for transcriptional activation of this gene mediated by progesterone receptor-ligand complexes. Relaxin, purported to enhance glycodelin production in vivo and in prior in vitro studies, had no stimulatory effect on the expression of this gene in vitro in our models.

KEYWORD

placental protein 14 - gene expression - progestins - relaxin

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