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Semin Respir Crit Care Med 2000; 21(2): 0135-0146
DOI: 10.1055/s-2000-9840
DOI: 10.1055/s-2000-9840
Bronchiolitis Obliterans Organizing Pneumonia
Jean-François Cordier- Hôpital Cardiovasculaire et Pneumologique Louis Pradel, Université Claude Bernard, 69394 Lyon, France
Further Information
Publication History
Publication Date:
03 March 2004 (online)
ABSTRACT
Bronchiolitis obliterans with organizing pneumonia (BOOP) is a pathological syndrome common to a variety of pulmonary inflammatory disorders. It is defined by the presence of buds of granulation tissue consisting of fibroblasts and collagen within the lumen of the distal airspaces. BOOP may be secondary to lung injury resulting especially from infection or drug toxicity or may develop in the context of connective tissue diseases or after lung or bone marrow transplantation. BOOP may also be idiopathic (and then preferentially called cryptogenic organizing pneumonia) and then is the hallmark of a distinct clinicoradiological syndrome of subacute pneumonia, with typical alveolar patchy and often migratory pulmonary opacities on imaging. Other imaging presentations consist of diffuse infiltrative opacities or focal pneumonia. Improvement with corticosteroids is usually spectacular, but relapses are common after stopping or while reducing treatment.
KEYWORD
Bronchiolitis obliterans organizing pneumonia (BOOP) - organizing pneumonia - interstitial lung disease
REFERENCES
- 1 Colby T V. Pathologic aspects of bronchiolitis obliterans organizing pneumonia. Chest . 1992; 102 38S-43S
- 2 Katzenstein A L, Askin F B. Katzenstein and Askin's surgical pathology of non-neoplastic lung disease. Philadelphia: W.B. Saunders 1997
- 3 Floyd R. Organization of pneumonitic exudates. Am J Med Sci . 1922; 163 527-548
- 4 Davison A G, Heard B E, McAllister W AC, Turner-Warwick M E. Cryptogenic organizing pneumonitis. QJM . 1983; 52 382-394
- 5 Epler G R, Colby T V, McLoud T C, Carrington C B, Gaensler E A. Bronchiolitis obliterans organizing pneumonia. N Engl J Med . 1985; 312 152-158
- 6 Katzenstein A L, Myers J L, Prophet W D, Corley III S L, Shin M S. Bronchiolitis obliterans and usual interstitial pneumonia. A comparative clinicopathologic study. Am J Surg Pathol . 1986; 10 373-381
- 7 Cordier J F, Loire R, Brune J. Idiopathic bronchiolitis obliterans organizing pneumonia. Definition of characteristic clinical profiles in a series of 16 patients. Chest . 1989; 96 999-1004
- 8 Guerry-Force M L, Muller N L, Wright J L. A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia, and small airways disease. Am Rev Respir Dis . 1987; 135 705-712
- 9 Bartter T, Irwin R S, Nash G, Balikian J P, Hollingsworth H H. Idiopathic bronchiolitis obliterans organizing pneumonia with peripheral infiltrates on chest roentgenogram. Arch Intern Med . 1989; 149 273-279
- 10 Kitaichi M. Differential diagnosis of bronchiolitis obliterans organizing pneumonia. Chest . 1992; 102 44S-49S
- 11 Uner A H, Rozum-Slota B, Katzenstein A L. Bronchiolitis obliterans-organizing pneumonia (BOOP)-like variant of Wegener's granulomatosis. A clinicopathologic study of 16 cases. Am J Surg Pathol . 1996; 20 794-801
- 12 Carrington C B, Addington W W, Goff A M. Chronic eosinophilic pneumonia. N Engl J Med . 1969; 280 787-798
- 13 Katzenstein A L, Fiorelli R F. Nonspecific interstitial pneumonia/fibrosis. Histologic features and clinical significance. Am J Surg Pathol . 1994; 18 136-147
- 14 Wagner A L, Szabunio M, Hazlett K S, Wagner S G. Radiologic manifestations of round pneumonia in adults. AJR Am J Roentgenol . 1998; 170 723-726
- 15 Kohno N, Ikezoe J, Johkoh T. Focal organizing pneumonia: CT appareance. Radiology . 1993; 189 119-123
- 16 Myers J L. Diagnosis of drug reactions in the lung. In: Churg A, Katzenstein ALA, eds. The lung: Current Concepts Philadelphia: Williams and Wilkins, 1993: 32-53
- 17 Dean P J, Groshart K D, Porterfield J G, Iansmith D H, Golden E B. Amiodarone-associated pulmonary toxicity. A clinical and pathologic study of eleven cases. Am J Clin Pathol . 1987; 87 7-13
- 18 Camus P, Lombard J N, Perrichon M. Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone. Thorax . 1989; 44 711-715
- 19 Oren S, Turkot S, Golzman B, London D, Ben-Dor D, Weiler Z. Amiodarone-induced bronchiolitis obliterans organizing pneumonia (BOOP). Respir Med . 1996; 90 167-169
- 20 Camus P, Piard F, Ashcroft T, Gal A A, Colby T V. The lung in inflammatory bowel disease. Medicine . 1993; 72 151-183
- 21 Hamadeh M A, Atkinson J, Smith L J. Sulfasalazine-induced pulmonary disease. Chest . 1992; 101 1033-1037
- 22 Swinburn C R, Jackson G J, Cobden I, Ashcroft T, Morritt G N, Corris P A. Bronchiolitis obliterans organising pneumonia in a patient with ulcerative colitis. Thorax . 1988; 43 735-736
- 23 Santrach P J, Askin F B, Wells R J, Azizkhan R G, Merten D F. Nodular form of bleomycin-related pulmonary injury in patients with osteogenic sarcoma. Cancer . 1989; 64 806-811
- 24 Glasier C M, Siegel M J. Multiple pulmonary nodules: Unusual manifestation of bleomycin toxicity. AJR . 1981; 137 155-156
- 25 Crestani B, Valeyre D, Roden S. Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. Am J Respir Crit Care Med . 1998; 158 1929-1935
- 26 Arbetter K R, Prakash U BS, Tazelaar H D, Douglas W W. Radiation-induced pneumonitis in the ``nonirradiated'' lung. Mayo Clin Proc . 1999; 74 27-36
- 27 Bayle J Y, Nesme P, Béjui-Thivolet F, Loire R, Guérin J C, Cordier J F. Migratory organizing pneumonitis ``primed'' by radiation therapy. Eur Respir J . 1995; 8 322-326
- 28 Martin C, Romero S, Sanchez-Paya J, Massuti B, Arriero J M, Hernandez L. Bilateral lymphocytic alveolitis: A common reaction after unilateral thoracic irradiation. Eur Respir J . 1999; 13 727-732
- 29 Roberts C M, Foulcher E, Zaunders J J. Radiation pneumonitis: A possible lymphocyte-mediated hypersensitivity reaction. Ann Intern Med . 1993; 118 696-700
- 30 Lynch J P, Belperio J, Flint A, Martinez F. Bronchiolar complications of connective tissue disorders. Semin Respir Crit Care Med . 1999; 20 149-168
- 31 Ippolito J A, Palmer L, Spector S, Kane P B, Gorevic P D. Bronchiolitis obliterans organizing pneumonia and rheumatoid arthritis. Semin Arthritis Rheum . 1993; 23 70-78
- 32 Tazelaar H D, Viggiano R W, Pickersgill J, Colby T V. Interstitial lung disease in polymyositis and dermatomyositis. Clinical features and prognosis as correlated with histologic findings. Am Rev Respir Dis . 1990; 141 727-733
- 33 Schwarz M I, Matthay R A, Sahn S A, Stanford R E, Marmorstein B L, Scheinhorn D J. Interstitial lung disease in polymyositis and dermatomyositis: Analysis of six cases and review of the literature. Medicine . 1976; 55 89-104
- 34 Takizawa H, Shiga J, Moroi Y, Miyachi S, Nishiwaki M, Miyamoto T. Interstitial lung disease in dermatomyositis: Clinicopathological study. J Rheumatol . 1987; 14 102-107
- 35 Akira M, Hara H, Sakatani M. Interstitial lung disease in association with polymyositis-dermatomyositis: Long-term folllow-up CT evaluation in seven patients. Radiology . 1999; 210 333-338
- 36 Ikezoe J, Johkoh T, Kohno N, Takeuchi N, Ichikado K, Nakamura H. High-resolution CT findings of lung disease in patients with polymyositis and dermatomyositis. J Thorac Imaging . 1996; 11 250-259
- 37 Fata F, Rathore R, Schiff C, Herzlich B C. Bronchiolitis obliterans organizing pneumonia as the first manifestation of polymyositis. South Med J . 1997; 90 227-230
- 38 Chan W M, Ip M, Lau C S, Wang E, Peh W CG. Anti-Jo1 syndrome presenting as cryptogenic organizing pneumonia. Respir Med . 1995; 89 639-641
- 39 Kalenian M, Zweiman B. Inflammatory myopathy, bronchiolitis obliterans/organizing pneumonia, and anti-Jo-1 antibodies-an interesting association. Clin Diagn Lab Immunol . 1997; 4 236-240
- 40 Schwarz M I, Sutarik J M, Nick J A, Leff J A, Emlen J W, Tuder R M. Pulmonary capillaritis and diffuse alveolar hemorrhage. A primary manifestation of polymyositis. Am J Respir Crit Care Med . 1995; 151 2037-2040
- 41 Yousem S A, Colby T V, Carrington C B. Lung biopsy in rheumatoid arthritis. Am Rev Respir Dis . 1985; 131 770-777
- 42 Siddiqui M T, Garrity E R, Husain A N. Bronchiolitis obliterans organizing pneumonia-like reactions: A nonspecific response or an atypical form of rejection of infection in lung allograft recipients?. Hum Pathol . 1996; 27 714-719
- 43 Chaparro C, Chamberlain D, Maurer J, Winton T, Dehoyos A, Kesten S. Bronchiolitis obliterans organizing pneumonia (BOOP) in lung transplant recipients. Chest . 1996; 110 1150-1154
- 44 Milne D S, Gascoigne A D, Ashcroft T. Organizing pneumonia following pulmonary transplantation and the development of obliterative bronchiolitis. Transplantation . 1994; S7 1757-1762
- 45 Egan J J, Sarker S, Hasleton P S, Woodcock A A, Yonan N, Deiraniya A K. Should cryptogenic organizing pneumonia be included in the classification of pulmonary allograft rejection?. J Heart Lung Transplant . 1996; 15 1268-1269
- 46 Abernathy E C, Hruban R H, Baumgartner W A, Reitz B A, Hutchins G M. The two forms of bronchiolitis obliterans in heart-lung transplant recipients. Hum Pathol . 1991; 22 1102-1110
- 47 Yousem S A. Small airway injury in heart-lung transplant recipients. Semin Respir Med . 1992; 13 85-93
- 48 Alasaly K, Muller N, Ostrow D N, Champion P, Fitzgerald J M. Cryptogenic organizing pneumonia. A report of 25 cases and a review of the literature. Medicine . 1995; 74 201-211
- 49 Mathew P, Bozeman P, Krance R A, Brenner M K, Heslop H E. Bronchiolitis obliterans organizing pneumonia (BOOP) in children after allogeneic bone marrow transplantation. Bone Marrow Transplant . 1994; 13 221-223
- 50 Battistini E, Dini G, Savioli C. Bronchiolitis obliterans organizing pneumonia in three children with acute leukaemias treated with cytosine arabinoside and anthracyclines. Eur Respir J . 1997; 10 1187-1190
- 51 Lohr R H, Boland B J, Douglas W W. Organizing pneumonia. Features and prognosis of cryptogenic, secondary, and focal variants. Arch Intern Med . 1997; 157 1323-1329
- 52 Chander K, Feldman L, Mahajan R. Spontaneous regression of lung metastases. Possible BOOP connection?. Chest . 1999; 115 601-602
- 53 Moya C, Anto J M, Taylor A J. Outbreak of organizing pneumonia in textile printing sprayers. Lancet . 1994; 343 498-502
- 54 Romero S, Hernandez L, Gil J, Aranda I, Martin C, Sanchez-Paya J. Organizing pneumonia in textile printing workers: A clinical description. Eur Respir J . 1998; 11 265-271
- 55 Muller N L, Guerry-Force M L, Staples C A. Differential diagnosis of bronchiolitis obliterans with organizing pneumonia and usual interstitial pneumonia: Clinical, functional, and radiologic findings. Radiology . 1987; 162 151-156
- 56 King Jr E T, Mortenson R L. Cryptogenic organizing pneumonitis. The North American Experience. Chest . 1992; 102 8S-13S
- 57 Costabel U, Teschler H, Schoenfeld B. BOOP in Europe. Chest . 1992; 101(Suppl) 14S-20S
- 58 Yamamoto M, Ina Y, Kitaichi M, Harasawa M, Tamura M. Clinical features of BOOP in Japan. Chest . 1992; 102 21S-215S
- 59 Izumi T, Kitaichi M, Nishimura K, Nagai S. Bronchiolitis obliterans organizing pneumonia. Clinical features and differential diagnosis. Chest . 1992; 102 715-719
- 60 Ackerman L V, Elliott G, Alanis M. Localized organizing pneumonia: Its resemblance to carcinoma. A review of its clinical roentgenographic and pathologic features. AJR Am J Roentgenol . 1954; 71 988-996
- 61 Flowers J R, Clunie G, Burke M, Constant O. Bronchiolitis obliterans organizing pneumonia: The clinical and radiological features of seven cases and a review of the literature. Clin Radiol . 1992; 45 371-377
- 62 Spiteri M A, Klernerman P, Sheppard M N, Padley S, Clark T J, Newman-Taylor A. Seasonal cryptogenic organising pneumonia with biochemical cholestasis: A new clinical entity. Lancet . 1992; 340 281-284
- 63 Johkoh T, Muller N L, Cartier Y. Idiopathic interstitial pneumonias: Diagnostic accuracy of thin-section CT in 129 patients. Radiology . 1999; 211 555-560
- 64 Akira M, Yamamoto S, Sakatani M. Bronchiolitis obliterans organizing pneumonia manifesting as multiple large nodules or masses. AJR Am J Roentgenol . 1998; 170 291-295
- 65 Lee K S, Kullnig P, Hartman T E, Müller N L. Cryptogenic organizing pneumonia: CT findings in 43 patients. AJR Am J Roentgenol . 1994; 162 543-546
- 66 Preidler K W, Szolar D M, Moelleken S, Tripp R, Schreyer H. Distribution pattern of computed tomography findings in patients with bronchiolitis obliterans organizing pneumonia. Invest Radiol . 1996; 31 251-255
- 67 Bouchardy L M, Kuhlman J E, Ball W C, Hruban R H, Askin F B, Siegelman S S. CT findings in bronchiolitis obliterans organizing pneumonia (BOOP) with radiographic, clinical, and histologic correlation. J Comput Assist Tomogr . 1993; 17 352-357
- 68 Chandler P W, Shin M S, Friedman S E, Myers J L, Katzenstein A L. Radiographic manifestations of bronchiolitis obliterans with organizing pneumonia vs usual interstitial pneumonia. AJR Am J Roentgenol . 1986; 147 899-906
- 69 Naccache J M, Wiesendanger T, Loire R, Cordier J F. Hypoxémie par shunt droit-gauche au cours de la BOOP. Rev Mal Resp . 1999; 16(suppl) 1S64-1S65
- 70 Costabel U, Teschler H, Guzman J. Bronchiolitis obliterans organizing pneumonia (BOOP): The cytological and immunocytological profile of bronchoalveolar lavage. Eur Respir J . 1992; 5 791-797
- 71 Nagai S, Aung H, Tanaka S. Bronchoalveolar lavage cell findings in patients with BOOP and related diseases. Chest . 1992; 102 32S-37S
- 72 Dina R, Sheppard M N. The histological diagnosis of clinically documented cases of cryptogenic organizing pneumonia: Diagnostic features in transbronchial biopsies. Histopathology . 1993; 23 541-545
- 73 Poletti V, Cazzato S, Minicuci N, Zompatori M, Burzi M, Schiattone M L. The diagnostic value of bronchoalveolar lavage and transbronchial lung biopsy in cryptogenic organizing pneumonia. Eur Respir J . 1996; 9 2513-2516
- 74 Lazor R, Vandevenne A, Pelletier A, Leclerc P, Court-Fortune I, Cordier J F, ``Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires''. Cryptogenic organizing pneumonia: Characteristics of relapses in a series of 48 patients. Am J Respir Crit Care Med . 1999; 159 A65
- 75 Epler G R. Bronchiolitis obliterans organizing pneumonia. Semin Respir Infect . 1995; 10 65-77
- 76 King T E. Bronchiolitis. In: Schwarz MI, King TE, eds. Interstitial Lung Disease Toronto: BC Decker, 1998: 645-684
- 77 Watanabe K, Senju S, Wen F Q, Shirakusa T, Maeda F, Yoshida M. Factors related to the relapse of bronchiolitis obliterans organizing pneumonia. Chest . 1998; 114 1599-1606
- 78 Yousem S A, Lohr R H, Colby T V. Idiopathic bronchiolitis obliterans organizing pneumonia/cryptogenic organizing pneumonia with unfavorable outcome: Pathologic predictors. Mod Pathol . 1997; 10 864-871
- 79 Cohen A J, King Jr E T, Downey G P. Rapidly progressive bronchiolitis obliterans with organizing pneumonia. Am J Respir Crit Care Med . 1994; 149 1670-1675
- 80 Nizami I Y, Kissner D G, Visscher D W, Dubaybo B A. Idiopathic bronchiolitis obliterans with organizing pneumonia. An acute and life-threatening syndrome. Chest . 1995; 108 271-277